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Sensitivity encoding for fast 1H MR spectroscopic imaging water reference acquisition
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Birch, Rebecca, Peet, Andrew C., Arvanitis, Theodoros N. and Wilson, Martin P. (2015) Sensitivity encoding for fast 1H MR spectroscopic imaging water reference acquisition. Magnetic Resonance in Medicine, 73 (6). pp. 2081-2086. doi:10.1002/mrm.25355 ISSN 0740-3194.
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Official URL: http://dx.doi.org/10.1002/mrm.25355
Abstract
Purpose: Accurate and fast 1H MR spectroscopic imaging (MRSI) water reference scans are important for absolute quantification of metabolites. However, the additional acquisition time required often precludes the water reference quantitation method for MRSI studies. Sensitivity encoding (SENSE) is a successful MR technique developed to reduce scan time. This study quantitatively assesses the accuracy of SENSE for water reference MRSI data acquisition, compared with the more commonly used reduced resolution technique. Methods: 2D MRSI water reference data were collected from a phantom and three volunteers at 3 Tesla for full acquisition (306 s); 2× reduced resolution (64 s) and SENSE R = 3 (56 s) scans. Water amplitudes were extracted using MRS quantitation software (TARQUIN). Intensity maps and Bland-Altman statistics were generated to assess the accuracy of the fast-MRSI techniques. Results: The average mean and standard deviation of differences from the full acquisition were 2.1 ± 3.2% for SENSE and 10.3 ± 10.7% for the reduced resolution technique, demonstrating that SENSE acquisition is approximately three times more accurate than the reduced resolution technique. Conclusion: SENSE was shown to accurately reconstruct water reference data for the purposes of in vivo absolute metabolite quantification, offering significant improvement over the more commonly used reduced resolution technique.
| Item Type: | Journal Article | ||||||||
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| Subjects: | R Medicine > RC Internal medicine | ||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Engineering > WMG (Formerly the Warwick Manufacturing Group) | ||||||||
| Library of Congress Subject Headings (LCSH): | Spectroscopic imaging, Metabolites -- Measurement | ||||||||
| Journal or Publication Title: | Magnetic Resonance in Medicine | ||||||||
| Publisher: | John Wiley & Sons, Inc. | ||||||||
| ISSN: | 0740-3194 | ||||||||
| Official Date: | June 2015 | ||||||||
| Dates: |
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| Volume: | 73 | ||||||||
| Number: | 6 | ||||||||
| Page Range: | pp. 2081-2086 | ||||||||
| DOI: | 10.1002/mrm.25355 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||
| Date of first compliant deposit: | 29 December 2015 | ||||||||
| Date of first compliant Open Access: | 29 December 2015 | ||||||||
| Funder: | Engineering and Physical Sciences Research Council (EPSRC), National Institute for Health Research (Great Britain) (NIHR) | ||||||||
| Grant number: | EP/F50053X/1 (EPSRC) | ||||||||
| Adapted As: |
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