The Library
Short echo time single voxel 1H magnetic resonance spectroscopy in the diagnosis and characterisation of pineal tumours in children
Tools
Harris, Lisa M., Davies, Nigel P., Wilson, Shaun, MacPherson, Lesley, Natarajan, Kal, English, Martin W., Brundler, Marie-Anne, Arvanitis, Theodoros N., Grundy, Richard G. and Peet, Andrew C. (2011) Short echo time single voxel 1H magnetic resonance spectroscopy in the diagnosis and characterisation of pineal tumours in children. Pediatric Blood & Cancer, Volume 57 (Number 6). pp. 972-977. doi:10.1002/pbc.23044 ISSN 1545-5009.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1002/pbc.23044
Abstract
Background:
Magnetic resonance spectroscopy (MRS) has been successful in characterising a range of brain tumours and is a useful aid to non-invasive diagnosis. The pineal region poses considerable surgical challenges and a major surgical resection is not required in the management of all tumours. Improved non-invasive assessment of pineal region tumours would be of considerable benefit.
Methods:
Single voxel MRS (TE 30 ms, TR 1500, 1.5 T) was performed on 15 pineal tumours: 5 germinomas, 1 non-germinomatous secreting germ cell tumour (GCT), 2 teratomas, 5 pineoblastomas, 1 pineal parenchymal tumour (PPT) of intermediate differentiation and 1 pineocytoma. Two germinomas outside the pineal gland were also studied. Metabolite, lipid and macromolecule concentrations were determined with LCModel™.
Results:
Germ cell tumours had significantly higher lipid and macromolecule concentrations than other tumours (t-test; P < 0.05). The teratomas had significantly lower total choline and creatine levels than germinomas (z test; P < 0.05). Taurine was convincingly detected in germinomas as well as PPTs.
Conclusions:
Magnetic resonance spectroscopy is useful for characterising pineal region tumours, aiding the non-invasive diagnosis and giving additional biological insight.
Item Type: | Journal Article | ||||
---|---|---|---|---|---|
Divisions: | Faculty of Science, Engineering and Medicine > Engineering > WMG (Formerly the Warwick Manufacturing Group) | ||||
Journal or Publication Title: | Pediatric Blood & Cancer | ||||
Publisher: | John Wiley & Sons, Inc. | ||||
ISSN: | 1545-5009 | ||||
Official Date: | 1 December 2011 | ||||
Dates: |
|
||||
Volume: | Volume 57 | ||||
Number: | Number 6 | ||||
Page Range: | pp. 972-977 | ||||
DOI: | 10.1002/pbc.23044 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |