Antonysunil, Adaikalakoteswari, Jayashri, Ramamurthy, Sukumar, Nithya, Venkataraman, Hema, Pradeepa, Rajendra, Gokulakrishnan, Kuppan, Anjana, Ranjit, McTernan, P. G., Tripathi, Gyanendra, Patel, Vinod, Kumar, Sudhesh, Mohan, Viswanathan and Saravanan, Ponnusamy (2014) Vitamin B12 deficiency is associated with adverse lipid profile in Europeans and Indians with type 2 diabetes. Cardiovascular Diabetology, Volume 13 (Number 1). pp. 1-7. Article number 129. doi:10.1186/s12933-014-0129-4 ISSN 1475-2840.
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Abstract
Background:
Metformin, a standard therapy in type 2 diabetes, reduces vitamin B12 levels. Studies linking low vitamin B12 levels and cardiovascular disease are equivocal and suggest improving B12 levels may help in primary prevention. The role of vitamin B12 deficiency on cardiovascular risk factors, especially in type 2 diabetes has not been explored. The aim of this study is to investigate whether vitamin B12 deficiency in type 2 diabetes patients is associated with cardiovascular risk factors in two different ethnic groups in UK and India.
Methods:
Type 2 diabetes patients from two secondary care diabetic centres (Europeans - UK and Indians - India) were studied. Serum vitamin B12, folate and biochemical parameters were measured.
Results:
The prevalence rates of vitamin B12 deficiency (<191 ng/L) were 27% and 12% in Europeans and Indians, respectively and higher in metformin treated type 2 diabetes patients. In linear regression analysis, after adjusting for all likely confounding factors, vitamin B12 independently associated with triglycerides in both the populations and cholesterol/HDL ratio in Indians. Logistic regression showed type 2 diabetes patients with vitamin B12 deficiency were at significantly higher odds of having coexisting coronary artery disease (CAD) in Europeans with similar but non-significant trend in Indians, after adjusting for all likely confounding factors.
Conclusions:
The prevalence of vitamin B12 deficiency is common in type 2 diabetes patients and is associated with adverse lipid parameters. Type 2 diabetes management guidelines should include the recommendation for regular testing for B12 levels, especially for those on metformin.
| Item Type: | Journal Article |
|---|---|
| Subjects: | R Medicine > RA Public aspects of medicine |
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Dean's Office & Professional Support Services Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
| Library of Congress Subject Headings (LCSH): | Diabetes, Vitamin B12 deficiency |
| Journal or Publication Title: | Cardiovascular Diabetology |
| Publisher: | Biomed central |
| ISSN: | 1475-2840 |
| Official Date: | 26 September 2014 |
| Dates: | Date Event 26 September 2014 Published 20 August 2014 Accepted 3 July 2014 Submitted |
| Volume: | Volume 13 |
| Number: | Number 1 |
| Number of Pages: | 7 |
| Page Range: | pp. 1-7 |
| Article Number: | Article number 129 |
| DOI: | 10.1186/s12933-014-0129-4 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Open Access (Creative Commons open licence) |
| Date of first compliant deposit: | 29 December 2015 |
| Date of first compliant Open Access: | 29 December 2015 |
| Funder: | Diabetes UK, George Eliot Hospital NHS Trust |
| Adapted As: | |
| URI: | https://wrap.warwick.ac.uk/66933/ |
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