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Uniting mathematics and biology for the control of visceral leishmaniasis
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Rock, Kat S., Rutte, Epke A. le, Vlas, S. J. de (Sake J.), Adams, Emily R., Medley, Graham and Hollingsworth, T. Déirdre (2015) Uniting mathematics and biology for the control of visceral leishmaniasis. Trends in Parasitology, Volume 31 (Number 6). pp. 251-259.
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Official URL: http://dx.doi.org/10.1016/j.pt.2015.03.007
Abstract
The neglected tropical disease (NTD) visceral leishmaniasis (VL) has been targeted by the WHO for elimination as a public health problem on the Indian subcontinent by 2017 or earlier. To date there is a surprising scarcity of mathematical models capable of capturing VL disease dynamics, which are widely considered central to planning and assessing the efficacy of interventions. The few models that have been developed are examined, highlighting the necessity for better data to parameterise and fit these and future models. In particular, the characterisation and infectiousness of the different disease stages will be crucial to elimination. Modelling can then assist in establishing whether, when, and how the WHO VL elimination targets can be met.
| Item Type: | Journal Article | ||||||
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| Subjects: | Q Science > QA Mathematics R Medicine > RA Public aspects of medicine |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) Faculty of Science, Engineering and Medicine > Science > Mathematics |
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| Library of Congress Subject Headings (LCSH): | Leishmaniasis -- Prevention | ||||||
| Journal or Publication Title: | Trends in Parasitology | ||||||
| Publisher: | Elsevier Science | ||||||
| ISSN: | 1471-4922 | ||||||
| Official Date: | June 2015 | ||||||
| Dates: |
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| Volume: | Volume 31 | ||||||
| Number: | Number 6 | ||||||
| Number of Pages: | 9 | ||||||
| Page Range: | pp. 251-259 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access | ||||||
| Funder: | Imperial College London, Bill & Melinda Gates Foundation | ||||||
| Grant number: | OPP1086560 (BMGF) |
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