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Uniting mathematics and biology for the control of visceral leishmaniasis

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Rock, Kat S., Rutte, Epke A. le, Vlas, S. J. de (Sake J.), Adams, Emily R., Medley, Graham and Hollingsworth, T. Déirdre (2015) Uniting mathematics and biology for the control of visceral leishmaniasis. Trends in Parasitology, Volume 31 (Number 6). pp. 251-259.

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Official URL: http://dx.doi.org/10.1016/j.pt.2015.03.007

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Abstract

The neglected tropical disease (NTD) visceral leishmaniasis (VL) has been targeted by the WHO for elimination as a public health problem on the Indian subcontinent by 2017 or earlier. To date there is a surprising scarcity of mathematical models capable of capturing VL disease dynamics, which are widely considered central to planning and assessing the efficacy of interventions. The few models that have been developed are examined, highlighting the necessity for better data to parameterise and fit these and future models. In particular, the characterisation and infectiousness of the different disease stages will be crucial to elimination. Modelling can then assist in establishing whether, when, and how the WHO VL elimination targets can be met.

Item Type: Journal Article
Subjects: Q Science > QA Mathematics
R Medicine > RA Public aspects of medicine
Divisions: Faculty of Science > Life Sciences (2010- )
Faculty of Science > Mathematics
Library of Congress Subject Headings (LCSH): Leishmaniasis -- Prevention
Journal or Publication Title: Trends in Parasitology
Publisher: Elsevier Science
ISSN: 1471-4922
Official Date: June 2015
Dates:
DateEvent
June 2015Published
22 April 2015Available
Volume: Volume 31
Number: Number 6
Number of Pages: 9
Page Range: pp. 251-259
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
Funder: Imperial College London, Bill & Melinda Gates Foundation
Grant number: OPP1086560 (BMGF)

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