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Approaches to the design of catalytic metallodrugs

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Soldevila-Barreda, Joan J. and Sadler, P. J. (2015) Approaches to the design of catalytic metallodrugs. Current Opinion in Chemical Biology, Volume 25 . pp. 172-183. doi:10.1016/j.cbpa.2015.01.024

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Official URL: http://dx.doi.org/10.1016/j.cbpa.2015.01.024

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Abstract

Metal ions are known to act as catalytic centres in metallo-enzymes. On the other hand, low-molecular-weight metal complexes are widely used as catalysts in chemical systems. However, small catalysts do not have a large protein ligand to provide substrate selectivity and minimize catalyst poisoning. Despite the challenges that the lack of a protein ligand might pose, some success in the use of metal catalysts for biochemical transformations has been reported. Here, we present a brief overview of such reports, especially involving catalytic reactions in cells. Examples include Csingle bondC bond formation, deprotection and functional group modification, degradation of biomolecules, and redox modulation. We discuss four classes of catalytic redox modulators: photosensitizers, superoxide dismutase mimics, thiol oxidants, and transfer hydrogenation catalysts. Catalytic metallodrugs offer the prospect of low-dose therapy and a challenging new design strategy for future exploration.

Item Type: Journal Article
Subjects: R Medicine > RC Internal medicine
Divisions: Faculty of Science > Chemistry
Library of Congress Subject Headings (LCSH): Metal catalysts -- Therapeutic use
Journal or Publication Title: Current Opinion in Chemical Biology
Publisher: Elsevier Ltd.
ISSN: 1367-5931
Official Date: 2015
Dates:
DateEvent
2015Published
12 March 2015Available
Volume: Volume 25
Number of Pages: 12
Page Range: pp. 172-183
DOI: 10.1016/j.cbpa.2015.01.024
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
Funder: European Research Council (ERC), Engineering and Physical Sciences Research Council (EPSRC), University of Warwick. Institute of Advanced Study (IAS), Birmingham Science City, European Regional Development Fund (ERDF), Advantage West Midlands (AWM)

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