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Approaches to the design of catalytic metallodrugs
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Soldevila-Barreda, Joan J. and Sadler, P. J. (2015) Approaches to the design of catalytic metallodrugs. Current Opinion in Chemical Biology, Volume 25 . pp. 172-183. doi:10.1016/j.cbpa.2015.01.024
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Official URL: http://dx.doi.org/10.1016/j.cbpa.2015.01.024
Abstract
Metal ions are known to act as catalytic centres in metallo-enzymes. On the other hand, low-molecular-weight metal complexes are widely used as catalysts in chemical systems. However, small catalysts do not have a large protein ligand to provide substrate selectivity and minimize catalyst poisoning. Despite the challenges that the lack of a protein ligand might pose, some success in the use of metal catalysts for biochemical transformations has been reported. Here, we present a brief overview of such reports, especially involving catalytic reactions in cells. Examples include Csingle bondC bond formation, deprotection and functional group modification, degradation of biomolecules, and redox modulation. We discuss four classes of catalytic redox modulators: photosensitizers, superoxide dismutase mimics, thiol oxidants, and transfer hydrogenation catalysts. Catalytic metallodrugs offer the prospect of low-dose therapy and a challenging new design strategy for future exploration.
| Item Type: | Journal Article | ||||||
|---|---|---|---|---|---|---|---|
| Subjects: | R Medicine > RC Internal medicine | ||||||
| Divisions: | Faculty of Science > Chemistry | ||||||
| Library of Congress Subject Headings (LCSH): | Metal catalysts -- Therapeutic use | ||||||
| Journal or Publication Title: | Current Opinion in Chemical Biology | ||||||
| Publisher: | Elsevier Ltd. | ||||||
| ISSN: | 1367-5931 | ||||||
| Official Date: | 2015 | ||||||
| Dates: |
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| Date of first compliant deposit: | 29 December 2015 | ||||||
| Volume: | Volume 25 | ||||||
| Number of Pages: | 12 | ||||||
| Page Range: | pp. 172-183 | ||||||
| DOI: | 10.1016/j.cbpa.2015.01.024 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access | ||||||
| Funder: | European Research Council (ERC), Engineering and Physical Sciences Research Council (EPSRC), University of Warwick. Institute of Advanced Study (IAS), Birmingham Science City, European Regional Development Fund (ERDF), Advantage West Midlands (AWM) |
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