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Water soluble triblock and pentablock poly(methacryloyl nucleosides) from copper-mediated living radical polymerisation using PEG macroinitiators
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Garcia, Margarita, Beecham, Matthew P., Kempe, Kristian, Haddleton, David M., Khan, Afzal and Marsh, Andrew (2015) Water soluble triblock and pentablock poly(methacryloyl nucleosides) from copper-mediated living radical polymerisation using PEG macroinitiators. European Polymer Journal, 66 . pp. 444-451. doi:10.1016/j.eurpolymj.2015.03.014 ISSN 0014-3057.
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Official URL: http://dx.doi.org/10.1016/j.eurpolymj.2015.03.014
Abstract
The monomers methacryloyl uridine and methacryloyl adenosine have been polymerised under copper-mediated living radical conditions using poly(ethylene glycol) (PEG) macroinitiators to give triblock and pentablock copolymers of reasonable dispersity. The triblocks were used as initiators for the successful synthesis of pentablock copolymers. The secondary structures of the triblock and pentablock copolymers have been investigated using circular dichroism (CD) spectroscopy. The adenosine copolymers are found to exhibit more ordered secondary structures in water in comparison to the uridine derived polymers. New supramolecular structure is observed by CD upon mixing adenosine and uridine triblock copolymers in water. The polymers obtained are of interest as potential drug delivery agents through interaction with small molecules and oligonucelotides.
Item Type: | Journal Article | ||||||||
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Subjects: | Q Science > QD Chemistry | ||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||
Library of Congress Subject Headings (LCSH): | Nucleosides, Circular dichroism | ||||||||
Journal or Publication Title: | European Polymer Journal | ||||||||
Publisher: | Pergamon | ||||||||
ISSN: | 0014-3057 | ||||||||
Official Date: | 14 March 2015 | ||||||||
Dates: |
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Volume: | 66 | ||||||||
Number of Pages: | 8 | ||||||||
Page Range: | pp. 444-451 | ||||||||
DOI: | 10.1016/j.eurpolymj.2015.03.014 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Funder: | Engineering and Physical Sciences Research Council (EPSRC), Rapra technology limited, University of Warwick | ||||||||
Grant number: | GR/L71933 (EPSRC) |
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