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Antidepressant medication in patients with advanced cancer : an observational study
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Lloyd-Williams, M., Payne, S., Reeve, Joanne L. and Kolamunnage Dona, R. (2013) Antidepressant medication in patients with advanced cancer : an observational study. QJM, Volume 106 (Number 11). pp. 995-1001. doi:10.1093/qjmed/hct133 ISSN 1460-2725.
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Official URL: http://dx.doi.org/10.1093/qjmed/hct133
Abstract
Objective: Literature reviews suggest limited evidence of efficacy of antidepressant medication in patients with advanced cancer. This study was carried out to observe the longitudinal effect of antidepressant medication in a cohort of advanced cancer patients.
Method: Patients were recruited from hospice day care settings and followed up longitudinally by series of measures for depression for 6 months or until death.
Results: Six hundred and twenty nine patients recruited. One hundred and fifty six patients in total (25%) were receiving antidepressant medication for a median of 9.5 weeks (range 0–36 weeks) and a mean of 12.2 weeks. There was no significant difference in scores on depression measures over time for patients receiving antidepressant medication.
Conclusions: Antidepressant medication for advanced cancer patients appeared to have little impact on depression scores. We postulate the holistic approaches within hospice day care may in themselves be interventions for depression thereby masking effect of pharmacological treatment. Further research should explore multi-intervention models for management of depression in advanced cancer.
Item Type: | Journal Article | ||||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Social Science & Systems in Health (SSSH) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | QJM | ||||||||
Publisher: | Oxford University Press | ||||||||
ISSN: | 1460-2725 | ||||||||
Official Date: | November 2013 | ||||||||
Dates: |
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Volume: | Volume 106 | ||||||||
Number: | Number 11 | ||||||||
Page Range: | pp. 995-1001 | ||||||||
DOI: | 10.1093/qjmed/hct133 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Restricted or Subscription Access |
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