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Parametric characterization of porous 3D bioscaffolds fabricated by an adaptive foam reticulation technique
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Winnett, James and Mallick, Kajal (2014) Parametric characterization of porous 3D bioscaffolds fabricated by an adaptive foam reticulation technique. JOM, Volume 66 (Number 4). pp. 590-597. doi:10.1007/s11837-014-0937-8 ISSN 1047-4838.
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Official URL: http://dx.doi.org/10.1007/s11837-014-0937-8
Abstract
Commercially pure titanium (Ti) and its alloys, in particular, titanium-vanadium-aluminium (Ti-6Al-4V), have been used as biomaterials due to their mechanical similarities to bone, good biocompatibility, and inertness in vivo. The introduction of porosity to the scaffolds leads to optimized mechanical properties and enhanced biological activity. The adaptive foam reticulation (AFR) technique has been previously used to generate hydroxyapatite bioscaffolds with enhanced cell behavior due to the generation of macroporous structures with microporous struts that provided routes for cell infiltration as well as attachment sites. Sacrificial polyurethane templates of 45 ppi and 90 ppi were coated in biomaterial-based slurries containing either Ti or Ti-6Al-4V as the biomaterial and camphene as the porogen. The resultant macropore sizes of 100–550 μm corresponded well with the initial template pore sizes while camphene produced micropores of 1–10 μm, with the level of microporosity related to the amount of porogen inclusion.
Item Type: | Journal Article | ||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Engineering > WMG (Formerly the Warwick Manufacturing Group) | ||||||
Journal or Publication Title: | JOM | ||||||
Publisher: | Springer New York LLC | ||||||
ISSN: | 1047-4838 | ||||||
Official Date: | 1 April 2014 | ||||||
Dates: |
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Volume: | Volume 66 | ||||||
Number: | Number 4 | ||||||
Page Range: | pp. 590-597 | ||||||
DOI: | 10.1007/s11837-014-0937-8 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Restricted or Subscription Access |
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