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Organic nitrate functional nanoparticles for the glutathione-triggered slow-release of nitric oxide
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Duong, Hien T. T., Ho, Amy, Davis, Thomas P. and Boyer, Cyrille (2014) Organic nitrate functional nanoparticles for the glutathione-triggered slow-release of nitric oxide. Journal of Polymer Science Part A: Polymer Chemistry, Volume 52 (Number 15). pp. 2099-2103. doi:10.1002/pola.27221 ISSN 0887-624X.
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Official URL: http://dx.doi.org/10.1002/pola.27221
Abstract
Nitrate-containing amphiphilic block copolymer chains were self-assembled into micellar nanostructures as a reservoir for the slow-release delivery of nitric oxide (NO). Poly(oligo(ethylene glycol) methyl ether methacrylate)-block-poly(vinyl benzyl chloride-co-styrene) was prepared by reversible addition fragmentation chain transfer (RAFT) polymerization. Pendant chloro- groups in the polymer backbone were reacted with silver nitrate (AgNO3) to introduce nitrate functionality. The nitrate-containing micelles proved to be stable in water, with no detectableNOrelease. The release ofNOwas then triggered by exposure to glutathione, and it was found that 36 and 99% of NO was released at 37 and 60° C, respectively, after 21 h.
Item Type: | Journal Article | ||||||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||||
Journal or Publication Title: | Journal of Polymer Science Part A: Polymer Chemistry | ||||||||||
Publisher: | John Wiley & Sons Ltd. | ||||||||||
ISSN: | 0887-624X | ||||||||||
Official Date: | 1 August 2014 | ||||||||||
Dates: |
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Volume: | Volume 52 | ||||||||||
Number: | Number 15 | ||||||||||
Page Range: | pp. 2099-2103 | ||||||||||
DOI: | 10.1002/pola.27221 | ||||||||||
Status: | Peer Reviewed | ||||||||||
Publication Status: | Published | ||||||||||
Access rights to Published version: | Restricted or Subscription Access |
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