Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Precious metal carborane polymer nanoparticles : characterisation of micellar formulations and anticancer activity

Tools
- Tools
+ Tools

Barry, Nicolas P. E., Pitto-Barry, Anaïs, Romero-Canelón, Isolda, Tran, Johanna, Soldevila-Barreda, Joan J., Hands-Portman, Ian, Smith, Corinne J., Kirby, Nigel, Dove, Andrew P., O'Reilly, Rachel K. and Sadler, P. J. (2014) Precious metal carborane polymer nanoparticles : characterisation of micellar formulations and anticancer activity. Faraday Discussions, 175 . pp. 229-240. doi:10.1039/c4fd00098f

[img]
Preview
PDF
WRAP_c4fd00098f.pdf - Published Version - Requires a PDF viewer.
Available under License Creative Commons Attribution.

Download (610Kb) | Preview
Official URL: http://dx.doi.org/10.1039/C4FD00098F

Request Changes to record.

Abstract

We report the encapsulation of highly hydrophobic 16-electron organometallic ruthenium and osmium carborane complexes [Ru/Os(p-cymene)(1,2-dicarba-closo-dodecarborane-1,2-dithiolate)] (1 and 2) in Pluronic® triblock copolymer P123 core–shell micelles. The spherical nanoparticles RuMs and OsMs, dispersed in water, were characterized by dynamic light scattering (DLS), cryogenic transmission electron microscopy (cryo-TEM), and synchrotron small-angle X-ray scattering (SAXS; diameter ca. 15 and 19 nm, respectively). Complexes 1 and 2 were highly active towards A2780 human ovarian cancer cells (IC50 0.17 and 2.50 μM, respectively) and the encapsulated complexes, as RuMs and OsMs nanoparticles, were less potent (IC50 6.69 μM and 117.5 μM, respectively), but more selective towards cancer cells compared to normal cells.

Item Type: Journal Article
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculty of Science > Chemistry
Faculty of Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Carboranes, Nanostructured materials, Antineoplastic agents
Journal or Publication Title: Faraday Discussions
Publisher: Royal Society of Chemistry
ISSN: 0301-7249
Official Date: 1 October 2014
Dates:
DateEvent
1 October 2014Available
16 June 2014Accepted
7 May 2014Submitted
Date of first compliant deposit: 29 December 2015
Volume: 175
Number of Pages: 12
Page Range: pp. 229-240
DOI: 10.1039/c4fd00098f
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
Funder: Leverhulme Trust (LT), University of Warwick, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung [Swiss National Science Foundation] (SNSF), European Research Council (ERC), Engineering and Physical Sciences Research Council (EPSRC), University of Warwick. Institute of Advanced Study (IAS), Birmingham Science City, Wellcome Trust (London, England)
Grant number: ECF-2013-414 (LT), RDF 2013-14 (UW), PA00P2_145308 (SNSF), PBNEP2_142949 (SNSF), 247450 (ERC), EP/G004897/1 (EPSRC), EP/F034210/1 (EPSRC), 055663/Z/98/Z (WT)

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics

twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us