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Precious metal carborane polymer nanoparticles : characterisation of micellar formulations and anticancer activity
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Barry, Nicolas P. E., Pitto-Barry, Anaïs, Romero-Canelón, Isolda, Tran, Johanna, Soldevila-Barreda, Joan J., Hands-Portman, Ian, Smith, Corinne J., Kirby, Nigel, Dove, Andrew P., O'Reilly, Rachel K. and Sadler, P. J. (2014) Precious metal carborane polymer nanoparticles : characterisation of micellar formulations and anticancer activity. Faraday Discussions, 175 . pp. 229-240. doi:10.1039/c4fd00098f
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Official URL: http://dx.doi.org/10.1039/C4FD00098F
Abstract
We report the encapsulation of highly hydrophobic 16-electron organometallic ruthenium and osmium carborane complexes [Ru/Os(p-cymene)(1,2-dicarba-closo-dodecarborane-1,2-dithiolate)] (1 and 2) in Pluronic® triblock copolymer P123 core–shell micelles. The spherical nanoparticles RuMs and OsMs, dispersed in water, were characterized by dynamic light scattering (DLS), cryogenic transmission electron microscopy (cryo-TEM), and synchrotron small-angle X-ray scattering (SAXS; diameter ca. 15 and 19 nm, respectively). Complexes 1 and 2 were highly active towards A2780 human ovarian cancer cells (IC50 0.17 and 2.50 μM, respectively) and the encapsulated complexes, as RuMs and OsMs nanoparticles, were less potent (IC50 6.69 μM and 117.5 μM, respectively), but more selective towards cancer cells compared to normal cells.
| Item Type: | Journal Article | ||||||||
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| Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) | ||||||||
| Divisions: | Faculty of Science > Chemistry Faculty of Science > Life Sciences (2010- ) |
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| Library of Congress Subject Headings (LCSH): | Carboranes, Nanostructured materials, Antineoplastic agents | ||||||||
| Journal or Publication Title: | Faraday Discussions | ||||||||
| Publisher: | Royal Society of Chemistry | ||||||||
| ISSN: | 0301-7249 | ||||||||
| Official Date: | 1 October 2014 | ||||||||
| Dates: |
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| Date of first compliant deposit: | 29 December 2015 | ||||||||
| Volume: | 175 | ||||||||
| Number of Pages: | 12 | ||||||||
| Page Range: | pp. 229-240 | ||||||||
| DOI: | 10.1039/c4fd00098f | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access | ||||||||
| Funder: | Leverhulme Trust (LT), University of Warwick, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung [Swiss National Science Foundation] (SNSF), European Research Council (ERC), Engineering and Physical Sciences Research Council (EPSRC), University of Warwick. Institute of Advanced Study (IAS), Birmingham Science City, Wellcome Trust (London, England) | ||||||||
| Grant number: | ECF-2013-414 (LT), RDF 2013-14 (UW), PA00P2_145308 (SNSF), PBNEP2_142949 (SNSF), 247450 (ERC), EP/G004897/1 (EPSRC), EP/F034210/1 (EPSRC), 055663/Z/98/Z (WT) |
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