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Prediction of resistance to chemotherapy in ovarian cancer : a systematic review

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Lloyd, Katherine L., Cree, Ian A. and Savage, Richard S. (2015) Prediction of resistance to chemotherapy in ovarian cancer : a systematic review. BMC Cancer, 15 (1). pp. 1-32. 117. doi:10.1186/s12885-015-1101-8

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Official URL: http://dx.doi.org/10.1186/s12885-015-1101-8

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Abstract

Background:
Patient response to chemotherapy for ovarian cancer is extremely heterogeneous and there are currently no tools to aid the prediction of sensitivity or resistance to chemotherapy and allow treatment stratification. Such a tool could greatly improve patient survival by identifying the most appropriate treatment on a patient-specific basis.

Methods:
PubMed was searched for studies predicting response or resistance to chemotherapy using gene expression measurements of human tissue in ovarian cancer.

Results:
42 studies were identified and both the data collection and modelling methods were compared. The majority of studies utilised fresh-frozen or formalin-fixed paraffin-embedded tissue. Modelling techniques varied, the most popular being Cox proportional hazards regression and hierarchical clustering which were used by 17 and 11 studies respectively. The gene signatures identified by the various studies were not consistent, with very few genes being identified by more than two studies. Patient cohorts were often noted to be heterogeneous with respect to chemotherapy treatment undergone by patients.

Conclusions:
A clinically applicable gene signature capable of predicting patient response to chemotherapy has not yet been identified. Research into a predictive, as opposed to prognostic, model could be highly beneficial and aid the identification of the most suitable treatment for patients.

Item Type: Journal Article
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculty of Science > Chemistry
Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Reproductive Health ( - until July 2016)
Faculty of Science > Centre for Systems Biology
Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Ovaries -- Tumors, Chemotherapy, Drug resistance
Journal or Publication Title: BMC Cancer
Publisher: BioMed Central Ltd.
ISSN: 1471-2407
Official Date: 11 March 2015
Dates:
DateEvent
11 March 2015Published
20 February 2015Accepted
8 August 2014Submitted
Volume: 15
Number: 1
Number of Pages: 32
Page Range: pp. 1-32
Article Number: 117
DOI: 10.1186/s12885-015-1101-8
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
Funder: Engineering and Physical Sciences Research Council (EPSRC), Medical Research Council (Great Britain) (MRC)
Grant number: EP/F500378/1 (EPSRC)

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