The Library
Simulation of alcohol action upon a detailed Purkinje neuron model and a simpler surrogate model that runs >400 times faster
Tools
Tools
Tools
Forrest, Michael D. (2015) Simulation of alcohol action upon a detailed Purkinje neuron model and a simpler surrogate model that runs >400 times faster. BMC Neuroscience, Volume 16 (Number 1). pp. 1-23. Article number 27. doi:10.1186/s12868-015-0162-6 ISSN 1471-2202.
|
PDF (Creative Commons : Attribution 4.0)
WRAP_12868_2015_Article_162 (1).pdf - Published Version - Requires a PDF viewer. Download (2462Kb) | Preview |
Official URL: http://dx.doi.org/10.1186/s12868-015-0162-6
Abstract
Background:
An approach to investigate brain function/dysfunction is to simulate neuron circuits on a computer. A problem, however, is that detailed neuron descriptions are computationally expensive and this handicaps the pursuit of realistic network investigations, where many neurons need to be simulated.
Results:
We confront this issue; we employ a novel reduction algorithm to produce a 2 compartment model of the cerebellar Purkinje neuron from a previously published, 1089 compartment model. It runs more than 400 times faster and retains the electrical behavior of the full model. So, it is more suitable for inclusion in large network models, where computational power is a limiting issue. We show the utility of this reduced model by demonstrating that it can replicate the full model’s response to alcohol, which can in turn reproduce experimental recordings from Purkinje neurons following alcohol application.
Conclusions:
We show that alcohol may modulate Purkinje neuron firing by an inhibition of their sodium-potassium pumps. We suggest that this action, upon cerebellar Purkinje neurons, is how alcohol ingestion can corrupt motor co-ordination. In this way, we relate events on the molecular scale to the level of behavior.
| Item Type: | Journal Article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Subjects: | Q Science > QP Physiology | ||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Computer Science | ||||||||
| Library of Congress Subject Headings (LCSH): | Purkinje cells, Alcohol -- Physiological effect | ||||||||
| Journal or Publication Title: | BMC Neuroscience | ||||||||
| Publisher: | BioMed Central Ltd. | ||||||||
| ISSN: | 1471-2202 | ||||||||
| Official Date: | 26 April 2015 | ||||||||
| Dates: |
|
||||||||
| Volume: | Volume 16 | ||||||||
| Number: | Number 1 | ||||||||
| Number of Pages: | 23 | ||||||||
| Page Range: | pp. 1-23 | ||||||||
| Article Number: | Article number 27 | ||||||||
| DOI: | 10.1186/s12868-015-0162-6 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||
| Date of first compliant deposit: | 29 December 2015 | ||||||||
| Date of first compliant Open Access: | 29 December 2015 | ||||||||
| Adapted As: | |||||||||
| Related URLs: |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
Downloads
Downloads per month over past year
