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CRH-R splicing in estrogen-sensitive breast cancer
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Grammatopoulos, Dimitris (2014) CRH-R splicing in estrogen-sensitive breast cancer. Cell Cycle, Volume 13 (Number 5). pp. 687-688. doi:10.4161/cc.27858
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Official URL: http://dx.doi.org/10.4161/cc.27858
Abstract
Alternative pre-mRNA splicing contributes in the acquired genomic alterations involved in the pathobiology of cancer development and progression.1 In normal biological systems, this mechanism allows protein complexity and diversity by increasing gene coding capacity and promoting expression of several related proteins with diverse and even antagonistic functions. However, in pathological settings such as cancer, mutations in splicing regulatory elements and/or alterations in the cellular splicing machinery can change splicing patterns and result in the generation of aberrantly spliced pre-mRNAs that favor development of the malignant state.
| Item Type: | Journal Article | ||||||||||
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| Subjects: | R Medicine > RC Internal medicine R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Breast--Cancer, Estrogen—Receptors , Breast|xCancer--Molecular aspects | ||||||||||
| Journal or Publication Title: | Cell Cycle | ||||||||||
| Publisher: | Landes Bioscience | ||||||||||
| ISSN: | 1538-4101 | ||||||||||
| Official Date: | 1 March 2014 | ||||||||||
| Dates: |
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| Volume: | Volume 13 | ||||||||||
| Number: | Number 5 | ||||||||||
| Page Range: | pp. 687-688 | ||||||||||
| DOI: | 10.4161/cc.27858 | ||||||||||
| Status: | Peer Reviewed | ||||||||||
| Publication Status: | Published | ||||||||||
| Access rights to Published version: | Open Access |
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