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CRH-R splicing in estrogen-sensitive breast cancer

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Grammatopoulos, Dimitris (2014) CRH-R splicing in estrogen-sensitive breast cancer. Cell Cycle, Volume 13 (Number 5). pp. 687-688. doi:10.4161/cc.27858

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Official URL: http://dx.doi.org/10.4161/cc.27858

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Abstract

Alternative pre-mRNA splicing contributes in the acquired genomic alterations involved in the pathobiology of cancer development and progression.1 In normal biological systems, this mechanism allows protein complexity and diversity by increasing gene coding capacity and promoting expression of several related proteins with diverse and even antagonistic functions. However, in pathological settings such as cancer, mutations in splicing regulatory elements and/or alterations in the cellular splicing machinery can change splicing patterns and result in the generation of aberrantly spliced pre-mRNAs that favor development of the malignant state.

Item Type: Journal Article
Subjects: R Medicine > RC Internal medicine
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016)
Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Breast--Cancer, Estrogen—Receptors , Breast|xCancer--Molecular aspects
Journal or Publication Title: Cell Cycle
Publisher: Landes Bioscience
ISSN: 1538-4101
Official Date: 1 March 2014
Dates:
DateEvent
1 March 2014Published
21 January 2014Available
28 October 2013Accepted
10 September 2013Submitted
Volume: Volume 13
Number: Number 5
Page Range: pp. 687-688
DOI: 10.4161/cc.27858
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access

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