Phillips, Daniel J. (2014) Biochemically adaptive materials based on (Iso)thermally-responsive polymers. PhD thesis, University of Warwick.

Preview

PDF WRAP_THESIS_Phillips_2014.pdf - Submitted Version - Requires a PDF viewer. Download (9Mb) | Preview

Request Changes to record.

Abstract

The ability to programme and manipulate small changes at the molecular level to elicit a dramatically enhanced macroscopic response makes “stimuli-responsive” materials a fascinating topic of study. This work seeks to manipulate the solubility switch associated with polymers exhibiting a Lower Critical Solution Temperature without a temperature change (‘isothermally’). This concept, as overviewed in Chapter 1, has attractive applications in biological settings where variations in in vivo microenvironments may be used to produce increasingly targeted delivery vehicles, and to mediate cell membrane interactions.

Using controlled radical polymerisation, pre-designed backbones, end-group(s) or side-chains can be targeted to control the hydrophilic-hydrophobic balance of a thermo-responsive system. Chapters 2 and 3 investigate this concept, using the chemical reduction of a functional polymer backbone or end-group to trigger isothermal polymer precipitation or solubilisation in linear and nanoparticle systems respectively. Chapter 4 applies a metal-ligand binding motif, prevalent in bacteria, to end-functional polymers as an alternative means of promoting isothermal polymer precipitation. This binding motif is then transferred to a nanoparticle system in Chapter 5, and used for the first time to prepare an optical, particle-based biosensor for the detection of physiologically relevant iron concentrations. Finally, Chapter 6 describes the enzymatic degradation of a polymer side-chain as a means of triggering isothermal precipitation and considers its potential to mediate cellular uptake.

In summary, a series of functionalised polymers and nanoparticles have been synthesised and their (isothermal) responses characterised. These materials may have exciting potential in the emerging field of nanomedicine.

Item Type:	Thesis or Dissertation (PhD)
Subjects:	Q Science > QD Chemistry Q Science > QR Microbiology
Library of Congress Subject Headings (LCSH):	Polymeric drug delivery systems, Polymers in medicine, Thermoresponsive polymers, Nanomedicine
Official Date:	September 2014
Dates:	Date Event September 2014 Submitted
Institution:	University of Warwick
Theses Department:	Department of Chemistry
Thesis Type:	PhD
Publication Status:	Unpublished
Supervisor(s)/Advisor:	Gibson, Matthew I.
Extent:	xxv, 263 leaves : illustrations (colour), charts.
Language:	eng

Request changes or add full text files to a record

Repository staff actions (login required)

View Item

Downloads