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Modelling transcriptional networks in leaf senescence
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Penfold, Christopher A. and Buchanan-Wollaston, Vicky (2014) Modelling transcriptional networks in leaf senescence. Journal of Experimental Botany, Volume 65 (Number 14). pp. 3859-3873. doi:10.1093/jxb/eru054 ISSN 0022-0957.
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Official URL: http://dx.doi.org/10.1093/jxb/eru054
Abstract
The process of leaf senescence is induced by an extensive range of developmental and environmental signals and controlled by multiple, cross-linking pathways, many of which overlap with plant stress-response signals. Elucidation of this complex regulation requires a step beyond a traditional one-gene-at-a-time analysis. Application of a more global analysis using statistical and mathematical tools of systems biology is an approach that is being applied to address this problem. A variety of modelling methods applicable to the analysis of current and future senescence data are reviewed and discussed using some senescence-specific examples. Network modelling with a senescence transcriptome time course followed by testing predictions with gene-expression data illustrates the application of systems biology tools.
Item Type: | Journal Article | ||||||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) Faculty of Science, Engineering and Medicine > Research Centres > Warwick Systems Biology Centre |
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Journal or Publication Title: | Journal of Experimental Botany | ||||||||||
Publisher: | Oxford University Press | ||||||||||
ISSN: | 0022-0957 | ||||||||||
Official Date: | 2014 | ||||||||||
Dates: |
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Volume: | Volume 65 | ||||||||||
Number: | Number 14 | ||||||||||
Page Range: | pp. 3859-3873 | ||||||||||
DOI: | 10.1093/jxb/eru054 | ||||||||||
Status: | Peer Reviewed | ||||||||||
Publication Status: | Published | ||||||||||
Access rights to Published version: | Restricted or Subscription Access |
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