UNSPECIFIED. (2004) Lack of dendritic cell maturation by the plant toxin ricin. EUROPEAN JOURNAL OF IMMUNOLOGY, 34 (8). pp. 2149-2157. ISSN 0014-2980

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Abstract

Several bacterial toxins either promote or inhibit the maturation of human monocyte-derived DC. Since the potent plant toxin ricin exploits the same cell entry pathway used by these bacterial toxins and shares identical catalytic activity with some of them, we have studied the capacity of ricin to induce DC maturation in vitro. Here, we show that in contrast to the bacterial proteins, ricin neither induces DC maturation nor interferes with LPS-induced DC maturation. There is no correlation between the absence of DC maturation and ricin dysfunction. Indeed, some of the ricin variants retain significant ribotoxicity and catalytic activity. We have extended these observations to ebulin-1, suggesting that this may be a general characteristic of plant-derived cytotoxic ribosome-inactivating toxins. The human immune system may therefore have evolved to recognize and rapidly respond to the bacterial proteins, whilst being less responsive to the equivalent plant cytotoxins. Understanding the effect of ricin on professional APC may provide insights into the generation of an anti-ricin vaccine and into the use of inactivated ricin A chains as delivery vectors as part of a vaccination protocol.

Item Type:	Journal Article
Subjects:	Q Science > QR Microbiology > QR180 Immunology
Journal or Publication Title:	EUROPEAN JOURNAL OF IMMUNOLOGY
Publisher:	WILEY-V C H VERLAG GMBH
ISSN:	0014-2980
Date:	August 2004
Volume:	34
Number:	8
Number of Pages:	9
Page Range:	pp. 2149-2157
Identification Number:	10.1002/eji.200425157
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/6775

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