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A polymorphism associated with entrepreneurship : evidence from dopamine receptor candidate genes

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Nicolaou, Nicos, Shane, Scott, Adi, Georgina, Mangino, Massimo and Harris, Juliette (2011) A polymorphism associated with entrepreneurship : evidence from dopamine receptor candidate genes. Small Business Economics, Volume 36 (Number 2). pp. 151-155. doi:10.1007/s11187-010-9308-1

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Official URL: http://dx.doi.org/10.1007/s11187-010-9308-1

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Abstract

The tendency to be an entrepreneur may be influenced by genetic variation. Sensation seeking is more common among entrepreneurs than among the general population. Twin studies show that the tendency to be an entrepreneur is heritable and that common genes influence both sensation seeking and entrepreneurial tendency (Nicolaou et al. Manag Sci 54:167–179, 2008a; Strateg Entrep J 2:7–21, 2008b). Since dopamine receptor genes have been associated with novelty seeking/sensation seeking (Benjamin et al. Nat Genet 12:81–84, 1996; Ebstein et al. Nat Genet 12:78–80, 1996; Noblett and Coccaro Curr Psychiatry Rep 7:73–80, 2005), and attention deficit hyperactivity disorder (ADHD) has been reported to occur at greater rates among entrepreneurs, we examined the association between five dopamine receptor genes and four ADHD-associated genes, with the tendency to be an entrepreneur in a sample of 1,335 individuals from the UK. We found a single nucleotide polymorphism (rs1486011) of the DRD3 gene on chromosome 3 to be significantly associated with the tendency to be an entrepreneur. This result is the first evidence of the association of a specific gene with entrepreneurship. Further studies are needed to replicate this association.

Item Type: Journal Article
Divisions: Faculty of Social Sciences > Warwick Business School > Entrepreneurship, Innovation & Management
Faculty of Social Sciences > Warwick Business School
Journal or Publication Title: Small Business Economics
Publisher: Springer New York LLC
ISSN: 0921-898X
Official Date: February 2011
Dates:
DateEvent
February 2011Published
Volume: Volume 36
Number: Number 2
Number of Pages: 4
Page Range: pp. 151-155
DOI: 10.1007/s11187-010-9308-1
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

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