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Performance of a non-invasive test for detecting mycobacterium bovis shedding in European badger (meles meles) populations
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King, Hayley C., Murphy, Andrew, James, Phillip, Travis, Emma Rachel, Porter, David, Sawyer, Jason, Cork, Jennifer, Delahay, Richard J., Gaze, William H., Courtenay, Orin and Wellington, E. M. H. (2015) Performance of a non-invasive test for detecting mycobacterium bovis shedding in European badger (meles meles) populations. Journal of Clinical Microbiology, 53 . pp. 2316-2323. doi:10.1128/JCM.00762-15
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WRAP-performance-nonivasive-test-detecting-bovis-shedding-badger-Wellington-2015.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (748Kb) | Preview |
Official URL: http://dx.doi.org/10.1128/JCM.00762-15
Abstract
The incidence of Mycobacterium bovis, the causative agent of bovine tuberculosis, in cattle herds in the United Kingdom is increasing, resulting in substantial economic losses. The European badger (Meles meles) is implicated as a wildlife reservoir and is the subject of control measures aimed at reducing incidence in cattle populations. Understanding the epidemiology of M. bovis in badger populations is essential to direct control interventions and understand disease spread; however, accurate diagnosis in live animals is challenging and currently uses invasive methods. Here we present a non-invasive diagnostic procedure and sampling regime using field sampling of latrines and detection of M. bovis with qPCR, the results of which strongly correlate with the results of immunoassay testing in the field at the social group level. This method allows M. bovis infection in badger populations to be monitored without trapping and provides additional information on the quantity of bacterial DNA shed. Our approach may therefore provide valuable insights into the epidemiology of bovine tuberculosis in badger populations and inform disease control interventions.
| Item Type: | Journal Article | ||||||||
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||
| Journal or Publication Title: | Journal of Clinical Microbiology | ||||||||
| Publisher: | American Society of Microbiology | ||||||||
| ISSN: | 0095-1137 | ||||||||
| Official Date: | July 2015 | ||||||||
| Dates: |
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| Volume: | 53 | ||||||||
| Page Range: | pp. 2316-2323 | ||||||||
| DOI: | 10.1128/JCM.00762-15 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access | ||||||||
| Open Access Version: |
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