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Vinfl unine in the treatment of bladder cancer
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Bachner, Mark and De Santis, Maria (2008) Vinfl unine in the treatment of bladder cancer. Therapeutics and Clinical Risk Managemen, Volume 4 (Number 6). pp. 1243-1253.
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Official URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC264310...
Abstract
Vinfl unine (VFL) is a third-generation bifl uorinated semi-synthetic vinca alkaloid
obtained by superacidic chemistry from its parent compound, vinorelbine. As with the other
vinca alkaloids, the main antineoplastic effects of VFL arise from its interaction with tubulin, the
major component of microtubules in mitotic spindles. In contrast to other vinca alkaloids, VFL
shows some distinctive properties in terms of tubulin binding, possibly explaining its superior
antitumor activity in vitro and in vivo compared with vinorelbine as well as its excellent safety
profi le. In transitional cell carcinoma (TCC), two single-agent phase II trials were performed
testing VFL in platinum-pretreated patients, showing moderate response rates and promising
disease control rates. Therefore, the fi rst phase III trial in modern times for second-line TCC
of the urothelium was designed in order to further investigate the activity of VFL. First results
were presented at the 2008 ASCO conference. VFL appears to be a possible treatment option
for patients with TCC progressing after fi rst-line platinum-containing chemotherapy.
Item Type: | Journal Item | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Cancer Research Unit Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Therapeutics and Clinical Risk Managemen | ||||
Publisher: | Dove Medical Press | ||||
ISSN: | 1176-6336 | ||||
Official Date: | 2008 | ||||
Dates: |
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Volume: | Volume 4 | ||||
Number: | Number 6 | ||||
Page Range: | pp. 1243-1253 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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