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Optimal management of metastatic castration-resistant prostate cancer : Highlights from a European Expert Consensus Panel

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Fitzpatrick, John M., Bellmunt, Joaquim, Fizazi, Karim, Heidenreich, Axel, Sternberg, Cora N., Tombal, Bertrand, Alcaraz, Antonio, Bahl, Amit, Bracarda, Sergio, Di Lorenzo, Giuseppe et al.
(2014) Optimal management of metastatic castration-resistant prostate cancer : Highlights from a European Expert Consensus Panel. European Journal of Cancer, Volume 50 (Number 9). pp. 1617-1627. doi:10.1016/j.ejca.2014.03.010

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Official URL: http://dx.doi.org/10.1016/j.ejca.2014.03.010

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Abstract

The exponential growth of novel therapies for the treatment of metastatic castration-resistant prostate cancer (mCRPC) over the last decade has created an acute need for education and guidance of clinicians regarding optimal strategies for patient management. A multidisciplinary panel of 21 European experts in mCRPC assembled for comprehensive discussion and consensus development, seeking to move the field forward and provide guidance and perspectives on optimal selection and sequencing of therapeutic agents and monitoring of response to treatment and disease progression. A total of 110 clinically-relevant questions were addressed and a modified Delphi method was utilised to obtain a consensus. The panel reached a consensus on several important issues, providing recommendations on appropriate phase III clinical trial end-points and optimal strategies for imaging and monitoring of bone metastases. Guidance regarding selection and sequencing of therapy in patients with newly diagnosed or progressive mCRPC is emphasised, including the use of novel bone-targeted agents, chemotherapy, androgen receptor pathway-targeted agents and immunotherapy. The impact of drug resistance and prostate-specific antigen flare on treatment decisions was also addressed. Ultimately, individualised therapy for patients with mCRPC is dependent on continued refinement of clinical decision-making based on patient and disease characteristics. This consensus statement offers clinicians expert guidance on the implementation of recent advances to improve patient outcome, focusing on the future of prostate cancer care.

Item Type: Journal Article
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Cancer Research Unit
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Oncology
Journal or Publication Title: European Journal of Cancer
Publisher: Pergamon
ISSN: 0959-8049
Official Date: June 2014
Dates:
DateEvent
June 2014Published
Volume: Volume 50
Number: Number 9
Page Range: pp. 1617-1627
DOI: 10.1016/j.ejca.2014.03.010
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Funder: Sanofi Aventis (Firm)

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