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Sleep duration and risk of fatal and nonfatal stroke : a prospective study and meta-analysis
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Leng, Yue, Cappuccio, Francesco, Wainwright, Nick W. J., Surtees, Paul G., Luben, Robert N., Brayne, Carol and Khaw, Kay-Tee (2015) Sleep duration and risk of fatal and nonfatal stroke : a prospective study and meta-analysis. Neurology, 84 (11). pp. 1072-1079. doi:10.1212/WNL.0000000000001371 ISSN 0028-3878.
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Official URL: http://dx.doi.org/10.1212/WNL.0000000000001371
Abstract
Objective:
To study the association between sleep duration and stroke incidence in a British population and to synthesize our findings with published results through a meta-analysis.
Methods:
The prospective study included 9,692 stroke-free participants aged 42-81 years from the European Prospective Investigation into Cancer-Norfolk cohort. Participants reported sleep duration in 1998-2000 and 2002-2004, and all stroke cases were recorded until March 31, 2009. For the meta-analysis, we searched Ovid Medline, EMBASE, and the Cochrane Library for prospective studies published until May 2014, and pooled effect estimates using a weighted random-effect model.
Results:
After 9.5 years of follow-up, 346 cases of stroke occurred. Long sleep was significantly associated with an increased risk of stroke (hazard ratio [HR] = 1.46 [95% confidence interval (CI) 1.08, 1.98]) after adjustment for all covariates. The association remained robust among those without preexisting diseases and those who reported sleeping well. The association for short sleep was smaller (and not statistically significant) (HR = 1.18 [95% CI 0.91, 1.53]). There was a higher stroke risk among those who reported persistently long sleep or a substantial increase in sleep duration over time, compared to those reporting persistently average sleep. These were compatible with the pooled HRs from an updated meta-analysis, which were 1.15 (1.07, 1.24) and 1.45 (1.30, 1.62) for short and long sleep duration, respectively.
Conclusions:
This prospective study and meta-analysis identified prolonged sleep as a potentially useful marker of increased future stroke risk in an apparently healthy aging population.
Item Type: | Journal Article | ||||||||
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Subjects: | Q Science > QP Physiology | ||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Sleep, Heart -- Diseases | ||||||||
Journal or Publication Title: | Neurology | ||||||||
Publisher: | Lippincott Williams & Wilkins | ||||||||
ISSN: | 0028-3878 | ||||||||
Official Date: | 17 March 2015 | ||||||||
Dates: |
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Volume: | 84 | ||||||||
Number: | 11 | ||||||||
Number of Pages: | 8 | ||||||||
Page Range: | pp. 1072-1079 | ||||||||
DOI: | 10.1212/WNL.0000000000001371 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Date of first compliant deposit: | 29 December 2015 | ||||||||
Date of first compliant Open Access: | 29 December 2015 | ||||||||
Funder: | Medical Research Council (Great Britain) (MRC), Cancer Research UK (CRUK) | ||||||||
Grant number: | G9502233 (MRC), G1000143 (MRC), SP2024/0204 (CRUK), C864/A14136 (CRUK) | ||||||||
Open Access Version: |
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