The Library
Genetic variants at chromosome 9p21 and risk of first versus subsequent coronary heart disease events
Tools
Tools
Tools
Patel, Riyaz S., Asselbergs, Folkert W., Quyyumi, Arshed A., Palmer, Tom M., Finan, Chris I., Tragante, Vinicius, Deanfield, John, Hemingway, Harry, Hingorani, Aroon D. and Holmes, Michael V. (2014) Genetic variants at chromosome 9p21 and risk of first versus subsequent coronary heart disease events. Journal of the American College of Cardiology, Volume 63 (Number 21). pp. 2234-2245. doi:10.1016/j.jacc.2014.01.065 ISSN 0735-1097.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1016/j.jacc.2014.01.065
Abstract
Objectives
The purpose of this analysis was to compare the association between variants at the chromosome 9p21 locus (Ch9p21) and risk of first versus subsequent coronary heart disease (CHD) events through systematic review and meta-analysis.
Background
Ch9p21 is a recognized risk factor for a first CHD event. However, its association with risk of subsequent events in patients with established CHD is less clear.
Methods
We searched PubMed and EMBASE for prospective studies reporting association of Ch9p21 with incident CHD events and extracted information on cohort type (individuals without prior CHD or individuals with established CHD) and effect estimates for risk of events.
Results
We identified 31 cohorts reporting on 193,372 individuals. Among the 16 cohorts of individuals without prior CHD (n = 168,209), there were 15,664 first CHD events. Ch9p21 was associated with a pooled hazard ratio (HR) of a first event of 1.19 (95% confidence interval: 1.17 to 1.22) per risk allele. In individuals with established CHD (n = 25,163), there were 4,436 subsequent events providing >99% and 91% power to detect a per-allele HR of 1.19 or 1.10, respectively. The pooled HR for subsequent events was 1.01 (95% confidence interval: 0.97 to 1.06) per risk allele. There was strong evidence of heterogeneity between the effect estimates for first and subsequent events (p value for heterogeneity = 5.6 × 10−11). We found no evidence for biases to account for these findings.
Conclusions
Ch9p21 shows differential association with risk of first versus subsequent CHD events. This has implications for genetic risk prediction in patients with established CHD and for mechanistic understanding of how Ch9p21 influences risk of CHD.
| Item Type: | Journal Article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
||||||||
| Journal or Publication Title: | Journal of the American College of Cardiology | ||||||||
| Publisher: | Elsevier Inc. | ||||||||
| ISSN: | 0735-1097 | ||||||||
| Official Date: | 3 June 2014 | ||||||||
| Dates: |
|
||||||||
| Volume: | Volume 63 | ||||||||
| Number: | Number 21 | ||||||||
| Page Range: | pp. 2234-2245 | ||||||||
| DOI: | 10.1016/j.jacc.2014.01.065 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Restricted or Subscription Access |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
