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Inhibition effect of a custom peptide on lung tumors
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Huang, Chih-Yu, Huang, Hsuan-Yu, Forrest, Michael D., Pan, Yun-Ru, Wu, Wei-Jen and Chen, Hueih-Min (2014) Inhibition effect of a custom peptide on lung tumors. PLoS One, 9 (10). e109174. doi:10.1371/journal.pone.0109174 ISSN 1932-6203.
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Official URL: http://dx.doi.org/10.1371/journal.pone.0109174
Abstract
Cecropin B is a natural antimicrobial peptide and CB1a is a custom, engineered modification of it. In vitro, CB1a can kill lung cancer cells at concentrations that do not kill normal lung cells. Furthermore, in vitro, CB1a can disrupt cancer cells from adhering together to form tumor-like spheroids. Mice were xenografted with human lung cancer cells; CB1a could significantly inhibit the growth of tumors in this in vivo model. Docetaxel is a drug in present clinical use against lung cancers; it can have serious side effects because its toxicity is not sufficiently limited to cancer cells. In our studies in mice: CB1a is more toxic to cancer cells than docetaxel, but dramatically less toxic to healthy cells.
Item Type: | Journal Article | ||||||||
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Subjects: | R Medicine > RC Internal medicine | ||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Computer Science | ||||||||
Library of Congress Subject Headings (LCSH): | Peptide antibiotics--Congresses, Peptides--Therapeutic use--Congresses, Microbial peptides, Lungs--Tumors--Treatment, Tumor antigens | ||||||||
Journal or Publication Title: | PLoS One | ||||||||
Publisher: | Public Library of Science | ||||||||
ISSN: | 1932-6203 | ||||||||
Official Date: | 13 October 2014 | ||||||||
Dates: |
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Volume: | 9 | ||||||||
Number: | 10 | ||||||||
Article Number: | e109174 | ||||||||
DOI: | 10.1371/journal.pone.0109174 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Date of first compliant deposit: | 29 December 2015 | ||||||||
Date of first compliant Open Access: | 29 December 2015 | ||||||||
Funder: | China. Guo jia ke xue ji shu bu [Ministry of Science and Technology], National Nano Device Laboratories | ||||||||
Grant number: | MOST 103-2221-E-492-032 | ||||||||
Embodied As: | 1 |
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