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Impact of temperature and pH value on the stability of hGHRH: An MD approach
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UNSPECIFIED. (2005) Impact of temperature and pH value on the stability of hGHRH: An MD approach. MATHEMATICAL AND COMPUTER MODELLING, 41 (10). pp. 1157-1170. ISSN 0895-7177
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Official URL: http://dx.doi.org/10.1016/j.mcm.2005.05.009
Abstract
In this work, we apply molecular dynamics to study the stability of growth hormone releasing factor (GHRH), in aqueous solution. The instabilities of the fragment GHRH(1-29) are well known from experimental studies and we performed simulations in order to verify the capability of molecular dynamics to predict unstable behaviours. We checked the occurrence of dynamical transitions of peptide conformation that increase or reduce chain flexibility and solvent exposure, depending on the macroscopical parameters pH and temperature. (c) 2005 Elsevier Ltd. All rights reserved.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QA Mathematics > QA76 Electronic computers. Computer science. Computer software Q Science > QA Mathematics |
| Journal or Publication Title: | MATHEMATICAL AND COMPUTER MODELLING |
| Publisher: | PERGAMON-ELSEVIER SCIENCE LTD |
| ISSN: | 0895-7177 |
| Date: | May 2005 |
| Volume: | 41 |
| Number: | 10 |
| Number of Pages: | 14 |
| Page Range: | pp. 1157-1170 |
| Identification Number: | 10.1016/j.mcm.2005.05.009 |
| Publication Status: | Published |
| URI: | http://wrap.warwick.ac.uk/id/eprint/6916 |
Data sourced from Thomson Reuters' Web of Knowledge
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