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The structure of a bioactive calcia-silica sol-gel glass
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UNSPECIFIED (2005) The structure of a bioactive calcia-silica sol-gel glass. JOURNAL OF MATERIALS CHEMISTRY, 15 (24). pp. 2369-2374. doi:10.1039/b501496d ISSN 0959-9428.
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Official URL: http://dx.doi.org/10.1039/b501496d
Abstract
We have used neutron diffraction with isotopic substitution to gain new insights into the nature of the atomic scale calcium environment in bioactive sol-gel glasses, and also used high energy X-ray total diffraction to probe the nature of the processes initiated when bioactive glass is immersed in vitro in simulated body fluid (SBF). Recent work has highlighted the potential of sol-gel derived calcium silicate glasses for the regeneration or replacement of damaged bone tissue. The mechanism of bioactivity and the requirements for optimisation of the properties of these materials are as yet only partially understood but have been strongly linked to calcium dissolution from the glass matrix. The data obtained point to a complex calcium environment in which calcium is loosely bound within the glass network and may therefore be regarded as facile. Complex multi-stage dissolution and mineral growth phases were observed as a function of reaction time between 1 min and 30 days, leading eventually to the formation of a disordered hydroxyapatite ( HA) layer on the glass surface, which is similar to the polycrystalline bone mineral hydroxyapatite. This methodology provides insight into the structure of key sites in these materials and key stages involved in their reactions, and thereby more generally into the behaviour of bone-regenerative materials that may facilitate improvements in tissue engineering applications.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QD Chemistry T Technology > TA Engineering (General). Civil engineering (General) |
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Journal or Publication Title: | JOURNAL OF MATERIALS CHEMISTRY | ||||
Publisher: | ROYAL SOC CHEMISTRY | ||||
ISSN: | 0959-9428 | ||||
Official Date: | 2005 | ||||
Dates: |
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Volume: | 15 | ||||
Number: | 24 | ||||
Number of Pages: | 6 | ||||
Page Range: | pp. 2369-2374 | ||||
DOI: | 10.1039/b501496d | ||||
Publication Status: | Published |
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