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Apoptosis and autophagy function cooperatively for the efficacious execution of programmed nurse cell death during Drosophila virilis oogenesis
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Velentzas, Athanassios D., Nezis, I. P., Stravopodis, Dimitrios J., Papassideri, Issidora S. and Margaritis, Lukas H. (2007) Apoptosis and autophagy function cooperatively for the efficacious execution of programmed nurse cell death during Drosophila virilis oogenesis. Autophagy, Volume 3 (Number 2). pp. 130-132. doi:10.4161/auto.3582 ISSN 1554-8627.
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Official URL: http://dx.doi.org/10.4161/auto.3582
Abstract
Programmed cell death consists of two major types, apoptotic and autophagic, both of which are mainly defined by morphological criteria. Our findings indicate that both types of programmed cell death occur in the ovarian nurse cells during middle and late oogenesis of Drosophila virilis. During mid-oogenesis, the spontaneously degenerated egg chambers exhibit typical characteristics of apoptotic cell death. Their nurse cells contain condensed chromatin and fragmented DNA, whereas active caspase assays and immunostaining procedures demonstrate the presence of highly activated caspases. Distinct features of autophagic cell death are also observed during D. virilis mid-oogenesis, as shown by monodansylcadaverine staining and ultrastructural examination performed by transmission electron microscopy. Additionally, atretic egg chambers exhibit an accumulation of lysosomal proteases. At the late stages of D. virilis oogenesis, apoptosis and autophagy coexist, manifesting cell death features that are similar to the ones described above, being also escorted by the involvement of an altered cytochrome c conformational display. We propose that apoptosis and autophagy operate synergistically during D. virilis oogenesis for a more efficient elimination of the degenerated nurse cells.
Item Type: | Journal Article | ||||||||||
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Subjects: | Q Science > QP Physiology | ||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||||
Library of Congress Subject Headings (LCSH): | Apoptosis, Drosophila, Oogenesis, Cell death | ||||||||||
Journal or Publication Title: | Autophagy | ||||||||||
Publisher: | Landes Bioscience | ||||||||||
ISSN: | 1554-8627 | ||||||||||
Official Date: | 2007 | ||||||||||
Dates: |
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Volume: | Volume 3 | ||||||||||
Number: | Number 2 | ||||||||||
Page Range: | pp. 130-132 | ||||||||||
DOI: | 10.4161/auto.3582 | ||||||||||
Status: | Peer Reviewed | ||||||||||
Publication Status: | Published | ||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||
Funder: | European Social Fund (ESF), Greece, National Resources Grants | ||||||||||
Grant number: | HRAKLEITOS 70/3/7164 |
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