GEMIG Study Invest (Including: UNSPECIFIED). (2005) Lack of association between common polymorphisms in genes of the renin-angiotensin system and mortality after myocardial infarction. CARDIOLOGY, 103 (4). pp. 185-188. ISSN 0008-6312

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Abstract

The insertion/deletion (I/D) polymorphism in the ACE gene and the A1166C polymorphism in the AT1R gene have been associated with left ventricular remodelling and prognosis after acute myocardial infarction ( AMI). We investigated whether these genetic variants associate with impaired left ventricular ejection fraction ( LVEF) and increased risk for in-hospital mortality after AMI. Consecutive AMI patients were recruited on admission and were genotyped for the above-mentioned polymorphisms. The frequency of the studied genotypes did not differ significantly between deceased patients and those who survived. The LVEF did not differ among patients with or without the DD genotype (45 +/- 10 vs. 45 +/- 10%, p=0.892) or the CC genotype (45 +/- 10 vs. 46 +/- 10%, p=0.859). These data question the role of the studied genotypes in the pathogenesis of AMI and do not support the previously supported hypothesis that these genotypes influence prognosis after AMI.

Item Type:	Journal Article
Subjects:	Q Science > QM Human anatomy
Journal or Publication Title:	CARDIOLOGY
Publisher:	KARGER
ISSN:	0008-6312
Date:	2005
Volume:	103
Number:	4
Number of Pages:	4
Page Range:	pp. 185-188
Identification Number:	10.1159/000084592
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/6950

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