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Cloned defective interfering influenza RNA and a 7 possible pan-specific treatment of respiratory virus 8 diseases

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Dimmock, N. J. and Easton, A. J. (Andrew J.) (2015) Cloned defective interfering influenza RNA and a 7 possible pan-specific treatment of respiratory virus 8 diseases. Viruses , 7 (7). pp. 3768-3788. doi:10.3390/v7072796

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Official URL: http://dx.doi.org/10.3390/v7072796

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Abstract

Defective interfering (DI) genomes are characterised by their ability to interfere with the 3 replication of the virus from which they were derived and other genetically compatible 4 viruses. DI genomes are synthesized by nearly all known viruses and represent a vast 5 natural reservoir of antivirals that can potentially be exploited for use in the clinic. This review 6 describes the application of DI virus to protect from virus-associated diseases in vivo using 7 as an example a highly active cloned influenza A DI genome and virus that protects broadly 8 in preclinical trials against different subtypes of influenza A and against non-influenza A 9 respiratory viruses. This influenza A-derived DI genome protects by two totally different 10 mechanisms: molecular interference with influenza A replication and by stimulating innate 11 immunity that acts against non-influenza A viruses. The review considers what is needed to 12 develop DI genomes to the point of entry into clinical trials.

Item Type: Journal Article
Subjects: Q Science > QR Microbiology > QR355 Virology
Divisions: Faculty of Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Influenza -- Genetic aspects -- Research, Influenza viruses -- Treatment , Respiratory organs -- Diseases, Antiviral agents
Journal or Publication Title: Viruses
Publisher: MDPI AG
ISSN: 1999-4915
Official Date: July 2015
Dates:
DateEvent
July 2015Available
3 July 2015Accepted
Date of first compliant deposit: 18 May 2016
Volume: 7
Number: 7
Page Range: pp. 3768-3788
DOI: 10.3390/v7072796
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
Funder: Wellcome Trust (London, England)

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