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Cloned defective interfering influenza RNA and a 7 possible pan-specific treatment of respiratory virus 8 diseases
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Dimmock, N. J. and Easton, A. J. (Andrew J.) (2015) Cloned defective interfering influenza RNA and a 7 possible pan-specific treatment of respiratory virus 8 diseases. Viruses , 7 (7). pp. 3768-3788. doi:10.3390/v7072796
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Official URL: http://dx.doi.org/10.3390/v7072796
Abstract
Defective interfering (DI) genomes are characterised by their ability to interfere with the 3 replication of the virus from which they were derived and other genetically compatible 4 viruses. DI genomes are synthesized by nearly all known viruses and represent a vast 5 natural reservoir of antivirals that can potentially be exploited for use in the clinic. This review 6 describes the application of DI virus to protect from virus-associated diseases in vivo using 7 as an example a highly active cloned influenza A DI genome and virus that protects broadly 8 in preclinical trials against different subtypes of influenza A and against non-influenza A 9 respiratory viruses. This influenza A-derived DI genome protects by two totally different 10 mechanisms: molecular interference with influenza A replication and by stimulating innate 11 immunity that acts against non-influenza A viruses. The review considers what is needed to 12 develop DI genomes to the point of entry into clinical trials.
| Item Type: | Journal Article | ||||||
|---|---|---|---|---|---|---|---|
| Subjects: | Q Science > QR Microbiology > QR355 Virology | ||||||
| Divisions: | Faculty of Science > Life Sciences (2010- ) | ||||||
| Library of Congress Subject Headings (LCSH): | Influenza -- Genetic aspects -- Research, Influenza viruses -- Treatment, Respiratory organs -- Diseases, Antiviral agents | ||||||
| Journal or Publication Title: | Viruses | ||||||
| Publisher: | MDPI AG | ||||||
| ISSN: | 1999-4915 | ||||||
| Official Date: | July 2015 | ||||||
| Dates: |
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| Volume: | 7 | ||||||
| Number: | 7 | ||||||
| Page Range: | pp. 3768-3788 | ||||||
| DOI: | 10.3390/v7072796 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access | ||||||
| Funder: | Wellcome Trust (London, England) |
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