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The hidden complexities in measurement of fructosyl-lysine and advanced glycation endproducts for risk prediction of vascular complications of diabetes
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Rabbani, Naila and Thornalley, Paul J. (2015) The hidden complexities in measurement of fructosyl-lysine and advanced glycation endproducts for risk prediction of vascular complications of diabetes. Diabetes, Volume 64 (Number 1). pp. 9-11. doi:10.2337/db14-1516 ISSN 0012-1797.
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Official URL: http://dx.doi.org/10.2337/db14-1516
Abstract
Diabetes is associated with increased glycation of proteins by glucose and methylglyoxal (MG). Early-stage glycation by glucose forms fructosamine adducts, mainly Ne-fructosyllysine (FL), which can be exploited for assessment of glycemic control in the measurement of A1C (FL and Na-fructosyl-valine). Later- or advanced-stage glycation processes involving degradation of FL and glycation of proteins by MG and related physiological dicarbonyl metabolites form advanced glycation end products (AGEs) (1). AGEs contribute to the pathogenesis of vascular complications of diabetes, and their measurement may provide improved complications-risk prediction.
Item Type: | Journal Article | ||||||
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Subjects: | R Medicine > RC Internal medicine | ||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Diabetes -- Complications, Blood-vessels -- Diseases, Arteries, Veins | ||||||
Journal or Publication Title: | Diabetes | ||||||
Publisher: | American Diabetes Association | ||||||
ISSN: | 0012-1797 | ||||||
Official Date: | January 2015 | ||||||
Dates: |
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Volume: | Volume 64 | ||||||
Number: | Number 1 | ||||||
Page Range: | pp. 9-11 | ||||||
DOI: | 10.2337/db14-1516 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Open Access (Creative Commons) |
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