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Cannabis use and the onset and course of mania : a systematic review and meta-analysis
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Gibbs, Melanie, Winsper, Catherine, Marwaha, Steven, Gilbert, Eleanor, Broome, Matthew R. and Singh, Swaran P. (2015) Cannabis use and the onset and course of mania : a systematic review and meta-analysis. Journal of Affective Disorders, Volume 15 (Number 171). pp. 39-47. doi:10.1016/j.jad.2014.09.016 ISSN 0165-0327.
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Official URL: http://dx.doi.org/10.1016/j.jad.2014.09.016
Abstract
BACKGROUND:
Whilst cannabis use appears to be a causal risk factor for the development of schizophrenia-related psychosis, associations with mania remain relatively unknown. This review aimed to examine the impact of cannabis use on the incidence of manic symptoms and on their occurrence in those with pre-existing bipolar disorder.
METHODS:
A systematic review of the scientific literature using the PRISMA guidelines. PsychINFO, Cochrane, Scopus, Embase and MEDLINE databases were searched for prospective studies.
RESULTS:
Six articles met inclusion criteria. These sampled 2391 individuals who had experienced mania symptoms. The mean length of follow up was 3.9 years. Studies support an association between cannabis use and the exacerbation of manic symptoms in those with previously diagnosed bipolar disorder. Furthermore, a meta-analysis of two studies suggests that cannabis use is associated with an approximately 3-fold (Odds Ratio: 2.97; 95% CI: 1.80-4.90) increased risk for the new onset of manic symptoms.
LIMITATIONS:
We were only able to identify a small number of studies of variable quality, thus our conclusions remain preliminary.
CONCLUSIONS:
Our findings whilst tentative, suggest that cannabis use may worsen the occurrence of manic symptoms in those diagnosed with bipolar disorder, and may also act as a causal risk factor in the incidence of manic symptoms. This underscores the importance of discouraging cannabis use among youth and those with bipolar disorder to help prevent chronic psychiatric morbidity. More high quality prospective studies are required to fully elucidate how cannabis use may contribute to the development of mania over time.
| Item Type: | Journal Article | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Subjects: | R Medicine > RC Internal medicine | ||||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Manic-depressive illness -- Prevention, Systematic reviews (Medical research) , Schizophrenia, Mania, Psychoses, Cannabis | ||||||||||
| Journal or Publication Title: | Journal of Affective Disorders | ||||||||||
| Publisher: | Elsevier Science BV | ||||||||||
| ISSN: | 0165-0327 | ||||||||||
| Official Date: | 15 January 2015 | ||||||||||
| Dates: |
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| Volume: | Volume 15 | ||||||||||
| Number: | Number 171 | ||||||||||
| Page Range: | pp. 39-47 | ||||||||||
| DOI: | 10.1016/j.jad.2014.09.016 | ||||||||||
| Status: | Peer Reviewed | ||||||||||
| Publication Status: | Published | ||||||||||
| Access rights to Published version: | Open Access (Creative Commons) |
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