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A photorhabdus natural product inhibits insect juvenile hormone epoxide hydrolase

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Nollmann , F. I., Heinrich, A. K., Brachmann, Alexander O., Morisseau, C. , Mukherjee, K., Casanova-Torres, A. M., Strobl, F., Kleinhans, D., Kinski, S., Schultz, K. et al.
(2015) A photorhabdus natural product inhibits insect juvenile hormone epoxide hydrolase. Chembiochem, Volume 16 (Number 5). pp. 766-771. doi:10.1002/cbic.201402650

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Abstract

Simple urea compounds ("phurealipids") have been identified from the entomopathogenic bacterium Photorhabdus luminescens, and their biosynthesis was elucidated. Very similar analogues of these compounds have been previously developed as inhibitors of juvenile hormone epoxide hydrolase (JHEH), a key enzyme in insect development and growth. Phurealipids also inhibit JHEH, and therefore phurealipids might contribute to bacterial virulence.

Item Type: Journal Article
Subjects: Q Science > QH Natural history > QH301 Biology
S Agriculture > SB Plant culture
Divisions: Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Microbiology & Infection
Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Biosynthesis, Insect nematodes, Natural products
Journal or Publication Title: Chembiochem
Publisher: Wiley-Blackwell Publishing Ltd.
ISSN: 1439-4227
Official Date: 23 March 2015
Dates:
DateEvent
23 March 2015Published
25 February 2015Available
7 November 2014Submitted
Volume: Volume 16
Number: Number 5
Page Range: pp. 766-771
DOI: 10.1002/cbic.201402650
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Funder: European Research Council (ERC), Seventh Framework Programme (European Commission) (FP7), LOEWE Zentrum für Insektenbiotechnologie & Bioressourcen (ZIB) [LOEWE Center for Insect Biotechnology & Bioresources], National Institute of Environmental Health Sciences (NIEHS), United States. Department of Agriculture (USDA), National Institutes of Health (U.S.) (NIH), Vietnam.Quỹ phát triển khoa học và công nghệ quốc gia [National Foundation for Science and Technology Development] (NAFOSTED), Deutscher Akademischer Austauschdienst (DAAD), Wellcome Trust (London, England), Thailand. Krasuang Suksathikan [Ministry of Education]
Grant number: 311477 (ECR), 602773 223328 (FP7), ES02710 (NIEHS), WIS01582 (USDA), T32 GM07215 (NIH), 106.06.16.09 (NAFOSTED), A/08/04969 (DAAD), 087769/Z/08/Z,

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