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The fine-scale genetic structure of the British population
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Wellcome Trust Case Control Consortium 2, International Multiple Sclerosis Genetics Consortium (Including: Leslie, S., Winney, B., Hellenthal, G., Davison, D., Boumertit, A., Day, T., Hutnik, K., Royrvik, E. C., Cunliffe, B., Lawson, D. J., Falush, D., Freeman, C., Pirinen, M., Myers, S., Robinson, M., Donnelly, P. and Bodmer, W.). (2015) The fine-scale genetic structure of the British population. Nature, 519 (7543). pp. 309-314. doi:10.1038/nature14230 ISSN 0028-0836.
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Official URL: http://dx.doi.org/10.1038/nature14230
Abstract
Fine-scale genetic variation between human populations is interesting as a signature of historical demographic events and because of its potential for confounding disease studies. We use haplotype-based statistical methods to analyse genome-wide single nucleotide polymorphism (SNP) data from a carefully chosen geographically diverse sample of 2,039 individuals from the United Kingdom. This reveals a rich and detailed pattern of genetic differentiation with remarkable concordance between genetic clusters and geography. The regional genetic differentiation and differing patterns of shared ancestry with 6,209 individuals from across Europe carry clear signals of historical demographic events. We estimate the genetic contribution to southeastern England from Anglo-Saxon migrations to be under half, and identify the regions not carrying genetic material from these migrations. We suggest significant pre-Roman but post-Mesolithic movement into southeastern England from continental Europe, and show that in non-Saxon parts of the United Kingdom, there exist genetically differentiated subgroups rather than a general ‘Celtic’ population.
Item Type: | Journal Article | ||||||||||
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Subjects: | D History General and Old World > DA Great Britain G Geography. Anthropology. Recreation > GN Anthropology Q Science > QH Natural history > QH426 Genetics |
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Population genetics -- Great Britain, Population geography , Britons -- Genealogy, Anglo-Saxon race -- Migrations, Celts | ||||||||||
Journal or Publication Title: | Nature | ||||||||||
Publisher: | Nature Publishing | ||||||||||
ISSN: | 0028-0836 | ||||||||||
Official Date: | 19 March 2015 | ||||||||||
Dates: |
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Volume: | 519 | ||||||||||
Number: | 7543 | ||||||||||
Page Range: | pp. 309-314 | ||||||||||
DOI: | 10.1038/nature14230 | ||||||||||
Status: | Peer Reviewed | ||||||||||
Publication Status: | Published | ||||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||||
Funder: | Wellcome Trust (London, England), National Health and Medical Research Council (Australia) (NHMRC) , Suomen Akatemia [Academy of Finland], Royal Society (Great Britain). Wolfson Research Merit Award (RSWRMA) | ||||||||||
Grant number: | (072974/Z/03/Z, 088262/Z/09/Z, 075491/Z/04/Z, 075491/Z/04/A, 075491/Z/04/B, 090532/Z/09/Z, 084818/Z/08/Z, 095552/Z/11/Z, 085475/Z/08/Z, 098387/Z/12/Z, 098386/Z/12/Z Wellcome Trust), (APP1053756 NHMRC), (257654 Suomen Akatemia), |
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