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Circulatory changes of the novel adipokine adipolin/CTRP12 in response to metformin treatment and an oral glucose challenge in humans
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Tan, Bee K., Chen, Jing, Hu, J., Amar, Omar, Mattu, Harman, Ramanjaneya, Manjunath, Patel, Vanlata H., Lehnert, Hendrik and Randeva, Harpal S. (2014) Circulatory changes of the novel adipokine adipolin/CTRP12 in response to metformin treatment and an oral glucose challenge in humans. Clinical Endocrinology, 81 (6). pp. 841-846. doi:10.1111/cen.12438
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Official URL: https://doi.org/10.1111/cen.12438
Abstract
OBJECTIVE:
Adipolin/CTRP12 is a novel adipokine with anti-inflammatory and glucose-lowering properties in rodents. We sought to investigate the effects of metformin treatment (850 mg twice daily for 6 months) and a 2 h 75 g oral glucose tolerance test (OGTT) on serum adipolin concentrations in humans.
DESIGN:
Cross-sectional study [PCOS (n = 83) and control (n = 39) subjects]. Serum adipolin was measured by ELISA. Metformin treatment (850 mg twice daily for 6 months) was offered to all women with PCOS, 34 women participated but 21 women completed 6 months of metformin therapy. Reasons for subjects not completing the study were nausea and gastrointestinal side effects (n = 4), pregnancies (n = 5), noncompliance (n = 2) and loss of contact (n = 2).
RESULTS:
Metformin treatment (850 mg twice daily for 6 months) substantially increased serum adipolin concentrations (P < 0·05) in women with polycystic ovary syndrome (PCOS), a pro-inflammatory state associated with obesity, diabetes, dyslipidaemia and atherosclerosis. Furthermore, changes in waist-hip ratio, glucose, triglycerides, CRP and carotid intima media thickness showed significant negative associations with changes in adipolin levels (P < 0·05, P < 0·01); in multiple regression analyses, only changes in glucose were predictive of changes in adipolin levels (β = -0·570, P = 0·009). Serum adipolin decreased significantly in response to the OGTT in PCOS and control subjects at 90 min (P < 0·05) and 120 min (P < 0·01).
CONCLUSIONS:
Adipolin and/or novel pharmacologic agents that increase adipolin's circulating concentrations might constitute a novel approach in the treatment of insulin resistant states.
| Item Type: | Journal Article | ||||||
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| Subjects: | Q Science > QP Physiology R Medicine > RC Internal medicine R Medicine > RM Therapeutics. Pharmacology |
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| Divisions: | Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) | ||||||
| Library of Congress Subject Headings (LCSH): | Cytokines, Metformin, Insulin resistance | ||||||
| Journal or Publication Title: | Clinical Endocrinology | ||||||
| Publisher: | Wiley-Blackwell Publishing Ltd | ||||||
| ISSN: | 0300-0664 | ||||||
| Official Date: | 8 December 2014 | ||||||
| Dates: |
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| Volume: | 81 | ||||||
| Number: | 6 | ||||||
| Page Range: | pp. 841-846 | ||||||
| DOI: | 10.1111/cen.12438 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||
| RIOXX Funder/Project Grant: |
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