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Ectopic expression of c-Myc in the skin affects the hair growth cycle and causes an enlargement of the sebaceous gland
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UNSPECIFIED. (2005) Ectopic expression of c-Myc in the skin affects the hair growth cycle and causes an enlargement of the sebaceous gland. BRITISH JOURNAL OF DERMATOLOGY, 152 (6). pp. 1125-1133. ISSN 0007-0963
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Official URL: http://dx.doi.org/10.1111/j.1365-2133.2005.06458.x
Abstract
Background The hair follicle continually undergoes dynamic remodelling in a cyclical manner involving tightly coordinated patterns of cell proliferation, differentiation and apoptosis. The oncoprotein c-Myc is a key regulator of these events in epidermal keratinocytes, but its importance in the hair growth cycle has not previously been determined. Objectives To determine the role of c-Myc in the hair growth cycle. Methods We characterized the hair follicle phenotype of transgenic mice that permit expression of a switchable form of c-Myc (c-Myc-ER (TM)) in the suprabasal epithelial layers of the epidermis and hair follicle. Results c-Myc activation increased epithelial cell proliferation in the outer root sheath and distal hair follicle, without any substantial alteration in levels of apoptosis. Moreover, chronic c-Myc activation resulted in marked desynchronization of the murine hair growth cycle, uncoupling of hair cycle-related skin thickness and enlargement of the sebaceous gland. Conclusions These data implicate c-Myc in the control of hair growth cycling and hair cycle-related epidermal and sebaceous gland homeostasis. We suggest that c-Myc may be activating follicular stem cells either directly or indirectly and that this has important implications for control of the 'hair cycle clock', hair growth and epidermal maintenance.
| Item Type: | Journal Article |
|---|---|
| Subjects: | R Medicine > RL Dermatology |
| Journal or Publication Title: | BRITISH JOURNAL OF DERMATOLOGY |
| Publisher: | BLACKWELL PUBLISHING |
| ISSN: | 0007-0963 |
| Date: | June 2005 |
| Volume: | 152 |
| Number: | 6 |
| Number of Pages: | 9 |
| Page Range: | pp. 1125-1133 |
| Identification Number: | 10.1111/j.1365-2133.2005.06458.x |
| Publication Status: | Published |
| URI: | http://wrap.warwick.ac.uk/id/eprint/6974 |
Data sourced from Thomson Reuters' Web of Knowledge
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