Ectopic expression of c-Myc in the skin affects the hair growth cycle and causes an enlargement of the sebaceous gland
UNSPECIFIED. (2005) Ectopic expression of c-Myc in the skin affects the hair growth cycle and causes an enlargement of the sebaceous gland. BRITISH JOURNAL OF DERMATOLOGY, 152 (6). pp. 1125-1133. ISSN 0007-0963Full text not available from this repository.
Official URL: http://dx.doi.org/10.1111/j.1365-2133.2005.06458.x
Background The hair follicle continually undergoes dynamic remodelling in a cyclical manner involving tightly coordinated patterns of cell proliferation, differentiation and apoptosis. The oncoprotein c-Myc is a key regulator of these events in epidermal keratinocytes, but its importance in the hair growth cycle has not previously been determined. Objectives To determine the role of c-Myc in the hair growth cycle. Methods We characterized the hair follicle phenotype of transgenic mice that permit expression of a switchable form of c-Myc (c-Myc-ER (TM)) in the suprabasal epithelial layers of the epidermis and hair follicle. Results c-Myc activation increased epithelial cell proliferation in the outer root sheath and distal hair follicle, without any substantial alteration in levels of apoptosis. Moreover, chronic c-Myc activation resulted in marked desynchronization of the murine hair growth cycle, uncoupling of hair cycle-related skin thickness and enlargement of the sebaceous gland. Conclusions These data implicate c-Myc in the control of hair growth cycling and hair cycle-related epidermal and sebaceous gland homeostasis. We suggest that c-Myc may be activating follicular stem cells either directly or indirectly and that this has important implications for control of the 'hair cycle clock', hair growth and epidermal maintenance.
|Item Type:||Journal Article|
|Subjects:||R Medicine > RL Dermatology|
|Journal or Publication Title:||BRITISH JOURNAL OF DERMATOLOGY|
|Number of Pages:||9|
|Page Range:||pp. 1125-1133|
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