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Hypersensitivity pneumonitis in workers exposed to metalworking fluids
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Barber, Christopher M, Burton, Clare M, Hendrick, David J., Pickering, Anthony C., Robertson, Alastair S., Robertson, Wendy and Sherwood Berge, P. (2014) Hypersensitivity pneumonitis in workers exposed to metalworking fluids. American Journal of Industrial Medicine, 57 (8). pp. 872-880. doi:10.1002/ajim.22337 ISSN 0271-3586 .
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Official URL: http://dx.doi.org/10.1002/ajim.22337
Abstract
Background This study used data from a large UK outbreak investigation, to develop and validate a new case definition for hypersensitivity pneumonitis due to metalworking fluid exposure (MWF-HP). Methods The clinical data from all workers with suspected MWF-HP were reviewed by an experienced panel of clinicians. A new MWF-HP Score was then developed to match the “gold standard” clinical opinion as closely as possible, using standard diagnostic criteria
that were relatively weighted by their positive predictive value.
Results The new case definition was reproducible, and agreed with expert panel opinion in 30/37 cases. This level of agreement was greater than with any of the three previously utilized case definitions (agreement in 16–24 cases). Where it was possible to calculate, the
MWF-HP Score also performed well when applied to 50 unrelated MWF-HP cases. Conclusions The MWF-HP Score offers a new case definition for use in future outbreaks. Am. J. Ind. Med. 57:872–880, 2014. � 2014 The Authors. American Journal of Industrial Medicine Published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is noncommercial and no modifications or adaptations are made.
Item Type: | Journal Article | ||||||||||
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Subjects: | R Medicine > RC Internal medicine | ||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Statistics and Epidemiology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Hypersensitivity pneumonitis -- Diagnosis, Metalworking fluids | ||||||||||
Journal or Publication Title: | American Journal of Industrial Medicine | ||||||||||
Publisher: | John Wiley & Sons, Inc. | ||||||||||
ISSN: | 0271-3586 | ||||||||||
Official Date: | August 2014 | ||||||||||
Dates: |
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Volume: | 57 | ||||||||||
Number: | 8 | ||||||||||
Page Range: | pp. 872-880 | ||||||||||
DOI: | 10.1002/ajim.22337 | ||||||||||
Status: | Peer Reviewed | ||||||||||
Publication Status: | Published | ||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||
RIOXX Funder/Project Grant: |
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