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Azinomycin inspired bisepoxides: influence of linker structure on in vitro cytotoxicity and DNA interstrand cross-linking
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UNSPECIFIED (2005) Azinomycin inspired bisepoxides: influence of linker structure on in vitro cytotoxicity and DNA interstrand cross-linking. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 15 (11). pp. 2861-2864. doi:10.1016/j.bcml.2005.03.091 ISSN 0960-894X.
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Official URL: http://dx.doi.org/10.1016/j.bcml.2005.03.091
Abstract
A series of bisepoxides based on the epoxide domain of the naturally occurring azinomycins have been synthesised. The incorporation of an aminomethyl group into the linker between the two alkylating epoxide units is shown to significantly enhance in vitro cytotoxicity against human tumour cell lines and DNA interstand cross-linking efficiency. (c) 2005 Elsevier Ltd. All rights reserved.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QD Chemistry | ||||
| Journal or Publication Title: | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | ||||
| Publisher: | PERGAMON-ELSEVIER SCIENCE LTD | ||||
| ISSN: | 0960-894X | ||||
| Official Date: | 2 June 2005 | ||||
| Dates: |
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| Volume: | 15 | ||||
| Number: | 11 | ||||
| Number of Pages: | 4 | ||||
| Page Range: | pp. 2861-2864 | ||||
| DOI: | 10.1016/j.bcml.2005.03.091 | ||||
| Publication Status: | Published |
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