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RAB GTPases and RAB-interacting proteins and their role in the control of cognitive functions
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D’Adamo, Patrizia, Masetti, Michela, Bianchi, Veronica, Morè, Lorenzo, Mignogna, Maria Lidia, Giannandrea, Maila and Gatti, Silvia (2014) RAB GTPases and RAB-interacting proteins and their role in the control of cognitive functions. Neuroscience & Biobehavioral Reviews, 46 (2). pp. 302-314. doi:10.1016/j.neubiorev.2013.12.009
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Official URL: http://dx.doi.org/10.1016/j.neubiorev.2013.12.009
Abstract
A RAS-related class of small monomeric G proteins, the RAB GTPases, is emerging as of key biological importance in compartment specific directional control of vesicles formation, transport and fusion. Thanks to human genetic observation and to the consequent dedicated biochemical work, substantial progress has been made on the understanding of the role played by RAB GTPases and their effector proteins on neuronal development and the shaping of cognitive functions. This review is highlighting these initial elements to broaden the current scope of research on developmental cognitive deficits and take the point of view of RAB GTPases control on membrane transport in neurons and astrocytes.
| Item Type: | Journal Article | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Subjects: | Q Science > QP Physiology | ||||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||||
| Library of Congress Subject Headings (LCSH): | G proteins, Developmental neurobiology | ||||||||||
| Journal or Publication Title: | Neuroscience & Biobehavioral Reviews | ||||||||||
| Publisher: | Pergamon | ||||||||||
| ISSN: | 0149-7634 | ||||||||||
| Official Date: | October 2014 | ||||||||||
| Dates: |
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| Volume: | 46 | ||||||||||
| Number: | 2 | ||||||||||
| Number of Pages: | 13 | ||||||||||
| Page Range: | pp. 302-314 | ||||||||||
| DOI: | 10.1016/j.neubiorev.2013.12.009 | ||||||||||
| Status: | Peer Reviewed | ||||||||||
| Publication Status: | Published | ||||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||||
| Funder: | Comitato Telethon Fondazione Onlus | ||||||||||
| Grant number: | TCP04015 |
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