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Podosome-regulating kinesin KIF1C translocates to the cell periphery in a CLASP-dependent manner

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Efimova, N., Grimaldi, Ashley D., Bachmann, Alice, Frye, K., Zhu, X., Feoktistov, A., Straube, Anne and Kaverina, Irina (2014) Podosome-regulating kinesin KIF1C translocates to the cell periphery in a CLASP-dependent manner. Journal of Cell Science, Volume 127 (Number 24). pp. 5179-5188. doi:10.1242/jcs.149633

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Official URL: http://dx.doi.org/10.1242/jcs.149633

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Abstract

The kinesin KIF1C is known to regulate podosomes, actin-rich adhesion structures that remodel the extracellular matrix during physiological processes. Here, we show that KIF1C is a player in the podosome-inducing signaling cascade. Upon induction of podosome formation by protein kinase C (PKC), KIF1C translocation to the cell periphery intensifies and KIF1C accumulates both in the proximity of peripheral microtubules that show enrichment for the plus-tip-associated proteins CLASPs and around podosomes. Importantly, without CLASPs, both KIF1C trafficking and podosome formation are suppressed. Moreover, chimeric mitochondrially targeted CLASP2 recruits KIF1C, suggesting a transient CLASP–KIF1C association. We propose that CLASPs create preferred microtubule tracks for KIF1C to promote podosome induction downstream of PKC.

Item Type: Journal Article
Divisions: Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology
Faculty of Medicine > Warwick Medical School
Journal or Publication Title: Journal of Cell Science
Publisher: The Company of Biologists Ltd.
ISSN: 0021-9533
Official Date: 15 December 2014
Dates:
DateEvent
15 December 2014Published
24 October 2014Available
Volume: Volume 127
Number: Number 24
Page Range: pp. 5179-5188
DOI: 10.1242/jcs.149633
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Description:

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