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Podosome-regulating kinesin KIF1C translocates to the cell periphery in a CLASP-dependent manner
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Efimova, N., Grimaldi, Ashley D., Bachmann, Alice, Frye, K., Zhu, X., Feoktistov, A., Straube, Anne and Kaverina, Irina (2014) Podosome-regulating kinesin KIF1C translocates to the cell periphery in a CLASP-dependent manner. Journal of Cell Science, Volume 127 (Number 24). pp. 5179-5188. doi:10.1242/jcs.149633 ISSN 0021-9533.
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Official URL: http://dx.doi.org/10.1242/jcs.149633
Abstract
The kinesin KIF1C is known to regulate podosomes, actin-rich adhesion structures that remodel the extracellular matrix during physiological processes. Here, we show that KIF1C is a player in the podosome-inducing signaling cascade. Upon induction of podosome formation by protein kinase C (PKC), KIF1C translocation to the cell periphery intensifies and KIF1C accumulates both in the proximity of peripheral microtubules that show enrichment for the plus-tip-associated proteins CLASPs and around podosomes. Importantly, without CLASPs, both KIF1C trafficking and podosome formation are suppressed. Moreover, chimeric mitochondrially targeted CLASP2 recruits KIF1C, suggesting a transient CLASP–KIF1C association. We propose that CLASPs create preferred microtubule tracks for KIF1C to promote podosome induction downstream of PKC.
| Item Type: | Journal Article | ||||||
|---|---|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Journal of Cell Science | ||||||
| Publisher: | The Company of Biologists Ltd. | ||||||
| ISSN: | 0021-9533 | ||||||
| Official Date: | 15 December 2014 | ||||||
| Dates: |
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| Volume: | Volume 127 | ||||||
| Number: | Number 24 | ||||||
| Page Range: | pp. 5179-5188 | ||||||
| DOI: | 10.1242/jcs.149633 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||
| Description: | Free access |
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