Murray, Joanna, Bottle, Alex, Sharland, Mike, Modi, Neena, Aylin, Paul, Majeed, Azeem, Saxena, Sonia, Modi, N., Brocklehurst, Peter, Abbott, J., Costeloe, Kate, Draper, E. S., Kemp, J., Ashby, Deborah, Young, Annie M. and Petrou, Stavros (2014) Risk factors for hospital admission with RSV bronchiolitis in England : a population-based birth cohort study. PLoS One, 9 (2). doi:10.1371/journal.pone.0089186 ISSN 1932-6203.

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Abstract

OBJECTIVE:
To examine the timing and duration of RSV bronchiolitis hospital admission among term and preterm infants in England and to identify risk factors for bronchiolitis admission.
DESIGN:
A population-based birth cohort with follow-up to age 1 year, using the Hospital Episode Statistics database.
SETTING:
71 hospitals across England.
PARTICIPANTS:
We identified 296618 individual birth records from 2007/08 and linked to subsequent hospital admission records during the first year of life.
RESULTS:
In our cohort there were 7189 hospital admissions with a diagnosis of bronchiolitis, 24.2 admissions per 1000 infants under 1 year (95%CI 23.7-24.8), of which 15% (1050/7189) were born preterm (47.3 bronchiolitis admissions per 1000 preterm infants (95% CI 44.4-50.2)). The peak age group for bronchiolitis admissions was infants aged 1 month and the median was age 120 days (IQR = 61-209 days). The median length of stay was 1 day (IQR = 0-3). The relative risk (RR) of a bronchiolitis admission was higher among infants with known risk factors for severe RSV infection, including those born preterm (RR = 1.9, 95% CI 1.8-2.0) compared with infants born at term. Other conditions also significantly increased risk of bronchiolitis admission, including Down's syndrome (RR = 2.5, 95% CI 1.7-3.7) and cerebral palsy (RR = 2.4, 95% CI 1.5-4.0).
CONCLUSIONS:
Most (85%) of the infants who are admitted to hospital with bronchiolitis in England are born at term, with no known predisposing risk factors for severe RSV infection, although risk of admission is higher in known risk groups. The early age of bronchiolitis admissions has important implications for the potential impact and timing of future active and passive immunisations. More research is needed to explain why babies born with Down's syndrome and cerebral palsy are also at higher risk of hospital admission with RSV bronchiolitis.

Item Type:	Journal Article
Subjects:	R Medicine > RJ Pediatrics
Divisions:	Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Clinical Trials Unit Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Bronchitis in children, Respiratory infections -- In infancy and childhood, Respiratory syncytial virus
Journal or Publication Title:	PLoS One
Publisher:	Public Library of Science
ISSN:	1932-6203
Official Date:	26 February 2014
Dates:	Date Event 26 February 2014 Published 16 January 2014 Accepted 11 October 2013 Submitted
Volume:	9
Number:	2
DOI:	10.1371/journal.pone.0089186
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access (Creative Commons)
RIOXX Funder/Project Grant:	Project/Grant ID RIOXX Funder Name Funder ID RP-PG-0707-10010 [NIHR] National Institute for Health Research http://dx.doi.org/10.13039/501100000272 UNSPECIFIED National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care (CLAHRC) Northwest London UNSPECIFIED UNSPECIFIED NIHR Imperial Biomedical Research Centre http://dx.doi.org/10.13039/501100013342

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