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The human endometrium as a sensor of embryo quality
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Macklon, N. S. and Brosens, Jan J. (2014) The human endometrium as a sensor of embryo quality. Biology of Reproduction, 91 (4). 98. doi:10.1095/biolreprod.114.122846 ISSN 0006-3363.
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Official URL: http://dx.doi.org/10.1095/biolreprod.114.122846
Abstract
Human reproduction is characterized by a high degree of embryo wastage, which is largely ascribed to a high prevalence of embryo aneuploidy. It is proposed that maternal strategies have evolved that prevent inappropriate investment in invasive, but poorly viable embryos. Key to this is the emerging concept of the endometrium as biosensor, first identified in human in vitro embryo/decidualized stromal cell coculture systems and recently confirmed in an in vivo mouse model. In this review, the growing supporting experimental evidence for the biosensor component of decidualized endometrium is outlined, and recent insights into the nature of the embryo-derived signal detected by the endometrium and the biological processes by which this signal is thought to be converted into a go or no-go endometrial response are described. Finally, the clinical implications of this new paradigm of the choosy uterus are addressed.
| Item Type: | Journal Article | ||||||||
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Reproductive Health ( - until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Biology of Reproduction | ||||||||
| Publisher: | Society for the Study of Reproduction | ||||||||
| ISSN: | 0006-3363 | ||||||||
| Official Date: | 1 October 2014 | ||||||||
| Dates: |
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| Volume: | 91 | ||||||||
| Number: | 4 | ||||||||
| Article Number: | 98 | ||||||||
| DOI: | 10.1095/biolreprod.114.122846 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||
| Related URLs: |
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