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Effects of neural androgen receptor disruption on aggressive behavior, arginine vasopressin and galanin systems in the bed nucleus of stria terminalis and lateral septum
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Marie-Luce, Clarisse, Raskin, Kalina, Bolborea, Matei, Monin, Marion, Picot, Marie and Mhaouty-Kodja, Sakina (2013) Effects of neural androgen receptor disruption on aggressive behavior, arginine vasopressin and galanin systems in the bed nucleus of stria terminalis and lateral septum. General and Comparative Endocrinology, 188 . pp. 218-225. doi:10.1016/j.ygcen.2013.03.031 ISSN 0016-6480.
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Official URL: http://dx.doi.org/10.1016/j.ygcen.2013.03.031
Abstract
In the present study, we investigated the role of the androgen receptor (AR) in the nervous system in the regulation of aggressive behavior and arginine vasopressin and galanin systems by testosterone. For this purpose, we used a conditional mouse line selectively lacking AR gene in the nervous system, backcrossed onto the C57BL/6J strain. Adult males were gonadectomized and supplemented with similar amounts of testosterone. When tested on two consecutive days in the resident intruder paradigm, fewer males of the mutant group exhibited aggressive behavior compared to their control littermates. In addition, a high latency to the first offensive attack was observed for the few animals that exhibited fighting behavior. This alteration was associated with a normal anogenital chemoinvestigation of intruder males. In olfactory discrimination tasks, sexual experience enhanced preference towards female-soiled bedding rather than male-soiled bedding and estrus females rather than intact males, regardless of genotype. This indicated that the behavioral alteration induced by neural AR mutation occurs in brain areas located downstream from the olfactory bulb. Quantification of the sexually dimorphic cell populations expressing preprovasopressin and galanin mRNAs in the bed nucleus of stria terminalis (BNST) and vasopressin-neurophysin 2 and galanin immunoreactivity in the lateral septum showed no significant differences between the two genotypes.
| Item Type: | Journal Article | ||||||
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| Subjects: | H Social Sciences > HM Sociology Q Science > QD Chemistry |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||
| Library of Congress Subject Headings (LCSH): | Aggressiveness, Arginine, Galanin | ||||||
| Journal or Publication Title: | General and Comparative Endocrinology | ||||||
| Publisher: | Academic Press | ||||||
| ISSN: | 0016-6480 | ||||||
| Official Date: | 1 July 2013 | ||||||
| Dates: |
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| Volume: | 188 | ||||||
| Page Range: | pp. 218-225 | ||||||
| DOI: | 10.1016/j.ygcen.2013.03.031 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||
| Description: | 26th Conference of European Comparative Endocrinologists |
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| Funder: | France. Agence nationale de la recherche (ANR), French agency for Food, Environmental and Occupational Health Safety (ANSES), Marie Curie Fellowship Association (MCFA) |
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