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Increased responses to the actions of fibroblast growth factor 21 on energy balance and body weight in a seasonal model of adiposity

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Murphy, M., Samms, R., Warner, A., Bolborea, Matei, Barrett, P., Fowler, M. J., Brameld, J. M., Tsintzas, K., Kharitonenkov, A., Adams, A. C., Coskun, T. and Ebling, F. J. P. (2013) Increased responses to the actions of fibroblast growth factor 21 on energy balance and body weight in a seasonal model of adiposity. Journal of Neuroendocrinology, 25 (2). pp. 180-189. doi:10.1111/j.1365-2826.2012.02383.x

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Official URL: http://dx.doi.org/10.1111/j.1365-2826.2012.02383.x

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Abstract

The present study aimed to investigate the actions of fibroblast growth factor 21 (FGF21) on energy balance in a natural model of relative fatness, the Siberian hamster. Hamsters were studied under long days (LD) to promote weight gain, or short days to induce weight loss, and treated with rhFGF21 (3 mg/kg/day) via s.c. minipumps for 14 days. On days 7–9, detailed assessments of ingestive behaviour, metabolic gas exchange and locomotor activity were made. FGF21 caused substantial (P < 0.0001) weight loss in the fat LD state but not in the lean SD state: at the end of the study, FGF21-treated hamsters in LD lost 18% of body weight compared to vehicle controls, which is comparable to the natural body weight loss observed in SD. Epididymal fat pads, a correlate of total carcass fat content, were reduced by 19% in FGF21 treated hamsters in LD, whereas no difference was found in SD. Body weight loss in LD was associated with a reduction in food intake (P < 0.001) and a decreased respiratory exchange ratio (P < 0.001), indicating increased fat oxidation. Treatment with FGF21 maintained the normal nocturnal increase in oxygen consumption and carbon dioxide production into the early light phase in hamsters in LD, indicating increased energy expenditure, although locomotor activity was unaffected. These data suggest a greater efficacy of FGF21 in hamsters in LD compared to those in SD, which is consistent with both the peripheral and possibly central actions of FGF21 with respect to promoting a lean phenotype. The observed differences in FGF21 sensitivity may relate to day length-induced changes in adipose tissue mass.

Item Type: Journal Article
Subjects: Q Science > QH Natural history
Divisions: Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Photoperiodism, Appetite, Fibroblasts
Journal or Publication Title: Journal of Neuroendocrinology
Publisher: Wiley-Blackwell Publishing Ltd.
ISSN: 0953-8194
Official Date: February 2013
Dates:
DateEvent
February 2013Published
24 January 2013Available
2 September 2012Accepted
18 April 2012Submitted
Volume: 25
Number: 2
Number of Pages: 10
Page Range: pp. 180-189
DOI: 10.1111/j.1365-2826.2012.02383.x
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Funder: Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC)
Grant number: BB/E020437/1

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