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LRH-1 : orphaned, adopted and needed for pregnancy
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Brosens, Jan J., Blanks, Andrew M. and Lucas, Emma S. (2014) LRH-1 : orphaned, adopted and needed for pregnancy. Nature Medicine, 19 (8). pp. 968-969. doi:10.1038/nm.3271 ISSN 1078-8956.
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Official URL: http://dx.doi.org/10.1038/nm.3271
Abstract
A new study shows that the orphan nuclear receptor liver receptor homolog 1 (LRH-1) wires the postovulatory rise in progesterone production to progesterone-dependent preparation of the endometrium for pregnancy, a process termed decidualization. Lack of Lrh-1 activity in either the ovary or uterus has catastrophic consequences for reproduction in mice...
| Item Type: | Journal Article | ||||
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| Subjects: | R Medicine > RG Gynecology and obstetrics | ||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Reproductive Health ( - until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Pregnancy -- Physiological aspects, Endometrium, Progesterone -- Receptors | ||||
| Journal or Publication Title: | Nature Medicine | ||||
| Publisher: | Nature Publishing Group | ||||
| ISSN: | 1078-8956 | ||||
| Official Date: | 6 August 2014 | ||||
| Dates: |
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| Volume: | 19 | ||||
| Number: | 8 | ||||
| Page Range: | pp. 968-969 | ||||
| DOI: | 10.1038/nm.3271 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Related URLs: |
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