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LRH-1 : orphaned, adopted and needed for pregnancy

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Brosens, Jan J., Blanks, Andrew M. and Lucas, Emma S. (2014) LRH-1 : orphaned, adopted and needed for pregnancy. Nature Medicine, 19 (8). pp. 968-969. doi:10.1038/nm.3271 ISSN 1078-8956.

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Official URL: http://dx.doi.org/10.1038/nm.3271

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Abstract

A new study shows that the orphan nuclear receptor liver receptor homolog 1 (LRH-1) wires the postovulatory rise in progesterone production to progesterone-dependent preparation of the endometrium for pregnancy, a process termed decidualization. Lack of Lrh-1 activity in either the ovary or uterus has catastrophic consequences for reproduction in mice...

Item Type: Journal Article
Subjects: R Medicine > RG Gynecology and obstetrics
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Reproductive Health ( - until July 2016)
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Pregnancy -- Physiological aspects, Endometrium, Progesterone -- Receptors
Journal or Publication Title: Nature Medicine
Publisher: Nature Publishing Group
ISSN: 1078-8956
Official Date: 6 August 2014
Dates:
DateEvent
6 August 2014Published
Volume: 19
Number: 8
Page Range: pp. 968-969
DOI: 10.1038/nm.3271
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
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