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Purinergic signalling during development and ageing
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Burnstock, Geoffrey and Dale, Nicholas (2015) Purinergic signalling during development and ageing. Purinergic Signalling, 11 (3). pp. 277-305. doi:10.1007/s11302-015-9452-9
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Official URL: http://dx.doi.org/10.1007/s11302-015-9452-9
Abstract
Extracellular purines and pyrimidines play major roles during embryogenesis, organogenesis, postnatal development and ageing in vertebrates, including humans. Pluripotent stem cells can differentiate into three primary germ layers of the embryo but may also be involved in plasticity and repair of the adult brain. These cells express the molecular components necessary for purinergic signalling, and their developmental fates can be manipulated via this signalling pathway. Functional P1, P2Y and P2X receptor subtypes and ectonucleotidases are involved in the development of different organ systems, including heart, blood vessels, skeletal muscle, urinary bladder, central and peripheral neurons, retina, inner ear, gut, lung and vas deferens. The importance of purinergic signalling in the ageing process is suggested by changes in expression of A1 and A2 receptors in old rat brains and reduction of P2X receptor expression in ageing mouse brain. By contrast, in the periphery, increases in expression of P2X3 and P2X4 receptors are seen in bladder and pancreas.
| Item Type: | Journal Article | ||||||
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| Subjects: | Q Science > QH Natural history Q Science > QP Physiology |
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| Divisions: | Faculty of Science > Life Sciences (2010- ) | ||||||
| Library of Congress Subject Headings (LCSH): | Stem cells, Purines--Receptors , Adenosine triphosphate , Aging | ||||||
| Journal or Publication Title: | Purinergic Signalling | ||||||
| Publisher: | Springer Netherlands | ||||||
| ISSN: | 1573-9538 | ||||||
| Official Date: | September 2015 | ||||||
| Dates: |
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| Volume: | 11 | ||||||
| Number: | 3 | ||||||
| Page Range: | pp. 277-305 | ||||||
| DOI: | 10.1007/s11302-015-9452-9 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Restricted or Subscription Access |
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