UNSPECIFIED. (2005) Compartmental modelling of the uptake kinetics of the anti-cancer agent topotecan in human breast cancer cells. INTERNATIONAL JOURNAL OF ADAPTIVE CONTROL AND SIGNAL PROCESSING, 19 (5). pp. 395-417. ISSN 0890-6327

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Abstract

A compartmental model for the in vitro uptake kinetics of the anti-cancer agent topotecan is proposed. This model provides a description of the activity of the drug, and subsequent delivery of active form to the nuclear DNA target. The unknown model parameters are estimated from two-photon laser-scanning microscopy data, which provide concentrations of topotecan (active plus inactive forms) in the extracellular region containing live human breast tumour cells (MCF-7 cell line), the cytoplasm and the nucleus. This determines an output structure for which the model is uniquely identifiable, that is, the unknown parameters are uniquely determined from noise-free, continuous and perfect data. The model allows in silico predictions of the dose dependence of target binding. Copyright © 2005 John Wiley & Sons, Ltd.

Item Type:	Journal Article
Subjects:	T Technology > TL Motor vehicles. Aeronautics. Astronautics T Technology > TK Electrical engineering. Electronics Nuclear engineering
Journal or Publication Title:	INTERNATIONAL JOURNAL OF ADAPTIVE CONTROL AND SIGNAL PROCESSING
Publisher:	JOHN WILEY & SONS LTD
ISSN:	0890-6327
Date:	June 2005
Volume:	19
Number:	5
Number of Pages:	23
Page Range:	pp. 395-417
Identification Number:	10.1002/acs.856
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/6998

Data sourced from Thomson Reuters' Web of Knowledge

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