Compartmental modelling of the uptake kinetics of the anti-cancer agent topotecan in human breast cancer cells
UNSPECIFIED. (2005) Compartmental modelling of the uptake kinetics of the anti-cancer agent topotecan in human breast cancer cells. INTERNATIONAL JOURNAL OF ADAPTIVE CONTROL AND SIGNAL PROCESSING, 19 (5). pp. 395-417. ISSN 0890-6327Full text not available from this repository.
Official URL: http://dx.doi.org/10.1002/acs.856
A compartmental model for the in vitro uptake kinetics of the anti-cancer agent topotecan is proposed. This model provides a description of the activity of the drug, and subsequent delivery of active form to the nuclear DNA target. The unknown model parameters are estimated from two-photon laser-scanning microscopy data, which provide concentrations of topotecan (active plus inactive forms) in the extracellular region containing live human breast tumour cells (MCF-7 cell line), the cytoplasm and the nucleus. This determines an output structure for which the model is uniquely identifiable, that is, the unknown parameters are uniquely determined from noise-free, continuous and perfect data. The model allows in silico predictions of the dose dependence of target binding. Copyright © 2005 John Wiley & Sons, Ltd.
|Item Type:||Journal Article|
|Subjects:||T Technology > TL Motor vehicles. Aeronautics. Astronautics
T Technology > TK Electrical engineering. Electronics Nuclear engineering
|Journal or Publication Title:||INTERNATIONAL JOURNAL OF ADAPTIVE CONTROL AND SIGNAL PROCESSING|
|Publisher:||JOHN WILEY & SONS LTD|
|Number of Pages:||23|
|Page Range:||pp. 395-417|
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