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Circadian chronotherapy for human cancers

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Lévi, Francis A. (2001) Circadian chronotherapy for human cancers. The Lancet. Oncology, Volume 2 (Number 5). pp. 307-315. doi:10.1016/s1470-2045(00)00326-0

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Official URL: http://dx.doi.org/10.1016/s1470-2045(00)00326-0

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Abstract

Cell physiology is regulated by a 24-hour clock, consisting of interconnected molecular loops, involving at least nine genes. The cellular clock is coordinated by the suprachiasmatic nucleus, a hypothalamic pacemaker which also helps the organism to adjust to environmental cycles. This circadian organisation brings about predictable changes in the body's tolerance and tumour responsiveness to anticancer agents, and possibly also for cancer promotion or growth. The clinical relevance of the chronotherapy principle, ie treatment regimens based upon circadian rhythms, has been demonstrated in randomised, multicentre trials. Chronotherapeutic schedules have been used to document the safety and activity of oxaliplatin against metastatic colorectal cancer and have formed the basis for a new approach to the medicosurgical management of this disease, which achieved unprecedented long-term survival. The chronotherapy concept offers further promise for improving current cancer-treatment options, as well as for optimising the development of new anticancer or supportive agents.

Item Type: Journal Article
Subjects: Q Science > QP Physiology
R Medicine > RC Internal medicine
Divisions: Faculty of Science, Engineering and Medicine > Research Centres > Warwick Systems Biology Centre
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Circadian rhythms , Cancer
Journal or Publication Title: The Lancet. Oncology
Publisher: The Lancet Publishing Group
ISSN: 1470-2045
Official Date: May 2001
Dates:
DateEvent
May 2001Published
Volume: Volume 2
Number: Number 5
Number of Pages: 9
Page Range: pp. 307-315
DOI: 10.1016/s1470-2045(00)00326-0
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

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