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Meniscal transplantation and its effect on osteoarthritis risk : an abridged protocol for the MeTEOR study : a comprehensive cohortstudy incorporating a pilot randomised controlled trial
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Smith, Nicholas A., Achten, Juul, Parsons, Nicholas R., Wright, D., Parkinson, B., Thompson, P., Hutchinson, Charles E., Spalding, Tim and Costa, Matthew L. (2015) Meniscal transplantation and its effect on osteoarthritis risk : an abridged protocol for the MeTEOR study : a comprehensive cohortstudy incorporating a pilot randomised controlled trial. Bone and joint research, 4 (6). pp. 93-98. doi:10.1302/2046-3758.46.2000318
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Official URL: http://dx.doi.org/10.1302/2046-3758.46.2000318
Abstract
Objectives:
Subtotal or total meniscectomy in the medial or lateral compartment of the knee results in a high risk of future osteoarthritis. Meniscal allograft transplantation has been performed for over thirty years with the scientifically plausible hypothesis that it functions in a similar way to a native meniscus. It is thought that a meniscal allograft transplant has a chondroprotective effect, reducing symptoms and the long-term risk of osteoarthritis. However, this hypothesis has never been tested in a high-quality study on human participants. This study aims to address this shortfall by performing a pilot randomised controlled trial within the context of a comprehensive cohort study design.
Methods:
Patients will be randomised to receive either meniscal transplant or a non-operative, personalised knee therapy program. MRIs will be performed every four months for one year. The primary endpoint is the mean change in cartilage volume in the weight-bearing area of the knee at one year post intervention. Secondary outcome measures include the mean change in cartilage thickness, T2 maps, patient-reported outcome measures, health economics assessment and complications.
Results:
This study is expected to report its findings in 2016.
| Item Type: | Journal Article | ||||||||||
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| Subjects: | R Medicine > RD Surgery | ||||||||||
| Divisions: | Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School > Health Sciences > Statistics and Epidemiology Faculty of Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Meniscectomy, Osteoarthritis -- Susceptibility | ||||||||||
| Journal or Publication Title: | Bone and joint research | ||||||||||
| Publisher: | British Editorial Society of Bone and Joint Surgery | ||||||||||
| ISSN: | 2046-3758 | ||||||||||
| Official Date: | 4 June 2015 | ||||||||||
| Dates: |
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| Volume: | 4 | ||||||||||
| Number: | 6 | ||||||||||
| Number of Pages: | 6 | ||||||||||
| Page Range: | pp. 93-98 | ||||||||||
| DOI: | 10.1302/2046-3758.46.2000318 | ||||||||||
| Status: | Peer Reviewed | ||||||||||
| Publication Status: | Published | ||||||||||
| Access rights to Published version: | Open Access | ||||||||||
| Funder: | Arthritis Research UK | ||||||||||
| Grant number: | 20149 |
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