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Circadian rhythms : mechanisms and therapeutic implications

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Lévi, Francis A. and Schibler, Ueli (2007) Circadian rhythms : mechanisms and therapeutic implications. Annual Review of Pharmacology and Toxicology, Volume 47 (Number 1). pp. 593-628. doi:10.1146/annurev.pharmtox.47.120505.105208 ISSN 0362-1642.

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Official URL: http://dx.doi.org/10.1146/annurev.pharmtox.47.1205...

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Abstract

The mammalian circadian system is organized in a hierarchical manner in that a central pacemaker in the suprachiasmatic nucleus (SCN) of the brain's hypothalamus synchronizes cellular circadian oscillators in most peripheral body cells. Fasting-feeding cycles accompanying rest-activity rhythms are the major timing cues in the synchronization of many, if not most, peripheral clocks, suggesting that the temporal coordination of metabolism and proliferation is a major task of the mammalian timing system. The inactivation of noxious food components by hepatic, intestinal, and renal detoxification systems is among the metabolic processes regulated in a circadian manner, with the understanding of the involved clock output pathways emerging. The rhythmic control of xenobiotic detoxification provides the molecular basis for the dosing time-dependence of drug toxicities and efficacy. This knowledge can in turn be used in improving or designing chronotherapeutics for the patients who suffer from many of the major human diseases.

Item Type: Journal Article
Subjects: Q Science > QP Physiology
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016)
Faculty of Science, Engineering and Medicine > Research Centres > Warwick Systems Biology Centre
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Circadian rhythms
Journal or Publication Title: Annual Review of Pharmacology and Toxicology
Publisher: Annual Reviews
ISSN: 0362-1642
Official Date: February 2007
Dates:
DateEvent
February 2007Published
Volume: Volume 47
Number: Number 1
Number of Pages: 36
Page Range: pp. 593-628
DOI: 10.1146/annurev.pharmtox.47.120505.105208
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Funder: Association pour la Recherche sur le Temps Biologique et la Chronothérapie (ARTBC International), Association pour le développement de la recherche sur le cancer (France), Sixth Framework Programme (European Commission) (FP6), Scientific Targeted Research Project Tempo, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung [Swiss National Science Foundation] (SNSF), Switzerland. National Centre of Competence in Research Frontiers in Genetics (NCCR FiG), Geneva (Switzerland : Canton), Bonizzi-Theler Foundation, Fondation Louis-Jeantet
Grant number: LSHB-CT-2004-005137 (FP6) ; LSHG-ct-2006-037543 (Scientific Targeted Research Project Tempo)

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