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Kinesins in cell migration
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Bachmann, Alice and Straube, Anne (2015) Kinesins in cell migration. Biochemical Society Transactions, Volume 43 (Number 1). pp. 79-83. doi:10.1042/BST20140280 ISSN 0300-5127.
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Official URL: http://dx.doi.org/10.1042/BST20140280
Abstract
Human cells express 45 kinesins, microtubule motors that transport a variety of molecules and organelles within the cell. Many kinesins also modulate the tracks they move on by either bundling or sliding or regulating the dynamic assembly and disassembly of the microtubule polymer. In migrating cells, microtubules control the asymmetry between the front and rear of the cell by differentially regulating force generation processes and substrate adhesion. Many of these functions are mediated by kinesins, transporters as well as track modulators. In this review, we summarize the current knowledge on kinesin functions in cell migration.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QH Natural history Q Science > QP Physiology |
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Kinesin, Cell migration | ||||
Journal or Publication Title: | Biochemical Society Transactions | ||||
Publisher: | Portland Press Ltd. | ||||
ISSN: | 0300-5127 | ||||
Official Date: | 1 February 2015 | ||||
Dates: |
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Volume: | Volume 43 | ||||
Number: | Number 1 | ||||
Number of Pages: | 5 | ||||
Page Range: | pp. 79-83 | ||||
DOI: | 10.1042/BST20140280 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Funder: | British Heart Foundation | ||||
Grant number: | FS/13/42/30377 |
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