Bachmann, Alice and Straube, Anne (2015) Kinesins in cell migration. Biochemical Society Transactions, Volume 43 (Number 1). pp. 79-83. doi:10.1042/BST20140280 ISSN 0300-5127.

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Abstract

Human cells express 45 kinesins, microtubule motors that transport a variety of molecules and organelles within the cell. Many kinesins also modulate the tracks they move on by either bundling or sliding or regulating the dynamic assembly and disassembly of the microtubule polymer. In migrating cells, microtubules control the asymmetry between the front and rear of the cell by differentially regulating force generation processes and substrate adhesion. Many of these functions are mediated by kinesins, transporters as well as track modulators. In this review, we summarize the current knowledge on kinesin functions in cell migration.

Item Type:	Journal Article
Subjects:	Q Science > QH Natural history Q Science > QP Physiology
Divisions:	Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Kinesin, Cell migration
Journal or Publication Title:	Biochemical Society Transactions
Publisher:	Portland Press Ltd.
ISSN:	0300-5127
Official Date:	1 February 2015
Dates:	Date Event 1 February 2015 Published
Volume:	Volume 43
Number:	Number 1
Number of Pages:	5
Page Range:	pp. 79-83
DOI:	10.1042/BST20140280
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	British Heart Foundation
Grant number:	FS/13/42/30377

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