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Gestational diabetes mellitus impairs fetal endothelial cell functions through a mechanism involving microRNA-101 and histone methyltransferase enhancer of zester homolog-2
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Floris, Ilaria, Descamps, Betty, Vardeu, Antonella, Mitić, Tijana, Posadino, Anna Maria, Shantikumar, Saran, Sala-Newby, Graciela, Capobianco, Gianpiero, Mangialardi, Giuseppe, Howard, Lynsey, Dessole, Salvatore, Urrutia, Raul, Pintus, Gianfranco and Emanueli, Costanza (2015) Gestational diabetes mellitus impairs fetal endothelial cell functions through a mechanism involving microRNA-101 and histone methyltransferase enhancer of zester homolog-2. Arteriosclerosis, Thrombosis, and Vascular Biology, 35 (3). pp. 664-674. doi:10.1161/ATVBAHA.114.304730
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Official URL: https://doi.org/10.1161/ATVBAHA.114.304730
Abstract
GDM impairs HUVEC function via miR-101 upregulation. EZH2 is both a transcriptional inhibitor and a target gene of miR-101 in HUVECs, and it contributes to some of the miR-101-induced defects of GDM-HUVECs.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Medicine > Warwick Medical School | ||||
| Journal or Publication Title: | Arteriosclerosis, Thrombosis, and Vascular Biology | ||||
| Publisher: | American Heart Association, Inc. | ||||
| ISSN: | 1079-5642 | ||||
| Official Date: | 9 January 2015 | ||||
| Dates: |
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| Volume: | 35 | ||||
| Number: | 3 | ||||
| Page Range: | pp. 664-674 | ||||
| DOI: | 10.1161/ATVBAHA.114.304730 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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